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. 1978 Nov;53(11):890–894. doi: 10.1136/adc.53.11.890

Growth and hormonal status of children treated for acute lymphoblastic leukaemia.

P G Swift, P J Kearney, R G Dalton, J A Bullimore, M G Mott, D C Savage
PMCID: PMC1545259  PMID: 281894

Abstract

Growth and hypothalamic-pituitary function have been studied in children in long-term remission from acute lymphoblastic leukaemia (ALL). All 14 children are growing and developing normally; in the 8 children in whom the hypothalamic pituitary axis was investigated endocrine function is normal. Continuing long-term review of these children is essential, but hypothalamic-pituitary investigation is required only when there is a decrease in growth velocity or delay in the onset of puberty.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dacou-Voutetakis C., Haidas S., Zannos-Mariolea L. Letter: Radiation and pituitary function in children. Lancet. 1975 Dec 13;2(7946):1206–1207. doi: 10.1016/s0140-6736(75)92692-6. [DOI] [PubMed] [Google Scholar]
  2. Ellis F. Dose, time and fractionation: a clinical hypothesis. Clin Radiol. 1969 Jan;20(1):1–7. doi: 10.1016/s0009-9260(69)80043-7. [DOI] [PubMed] [Google Scholar]
  3. Hustu H. O., Aur R. J., Verzosa M. S., Simone J. V., Pinkel D. Prevention of central nervous system leukemia by irradiation. Cancer. 1973 Sep;32(3):585–597. doi: 10.1002/1097-0142(197309)32:3<585::aid-cncr2820320311>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
  4. Lawrence A. M., Pinsky S. M., Goldfine I. D. Conventional radiation therapy in acromegaly. A review and reassessment. Arch Intern Med. 1971 Sep;128(3):369–377. [PubMed] [Google Scholar]
  5. Mauer A. M., Simone J. V. The current status of the treatment of childhood acute lymphoblastic leukemia. Cancer Treat Rev. 1976 Mar;3(1):17–41. doi: 10.1016/s0305-7372(76)80015-1. [DOI] [PubMed] [Google Scholar]
  6. McNeilly A. S., Hagen C. Prolactin, TSH, LH and FSH responses to a combined LHRH-TRH test at different stages of the menstrual cycle. Clin Endocrinol (Oxf) 1974 Oct;3(4):427–435. doi: 10.1111/j.1365-2265.1974.tb02813.x. [DOI] [PubMed] [Google Scholar]
  7. Refetoff S., Harrison J., Karanfilski B. T., Kaplan E. L., De Groot L. J., Bekerman C. Continuing occurrence of thyroid carcinoma after irradiation to the neck in infancy and childhood. N Engl J Med. 1975 Jan 23;292(4):171–175. doi: 10.1056/NEJM197501232920402. [DOI] [PubMed] [Google Scholar]
  8. Richards G. E., Wara W. M., Grumbach M. M., Kaplan S. L., Sheline G. E., Conte F. A. Delayed onset of hypopituitarism: sequelae of therapeutic irradiation of central nervous system, eye, and middle ear tumors. J Pediatr. 1976 Oct;89(4):553–559. doi: 10.1016/s0022-3476(76)80385-x. [DOI] [PubMed] [Google Scholar]
  9. Savage D. C., Swift P. G., Johnston P. G., Goldie D. J., Murphy D. Combined test of anterior pituitary function in children. Arch Dis Child. 1978 Apr;53(4):301–304. doi: 10.1136/adc.53.4.301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Schiliro G., Russo A., Sciotto A., Distefano G., Vigo R. Radiotherapy, chemotherapy, and growth-hormone deficiency. Lancet. 1976 Nov 6;2(7993):1031–1032. doi: 10.1016/s0140-6736(76)90881-3. [DOI] [PubMed] [Google Scholar]
  11. Shalet S. M., Beardwell C. G., Jones P. H., Pearson D. Growth hormone deficiency after treatment of acute leukaemia in children. Arch Dis Child. 1976 Jul;51(7):489–493. doi: 10.1136/adc.51.7.489. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Shalet S. M., Beardwell C. G., Morris-Jones P. H., Pearson D. Pituitary function after treatment of intracranial tumours in children. Lancet. 1975 Jul 19;2(7925):104–107. doi: 10.1016/s0140-6736(75)90006-9. [DOI] [PubMed] [Google Scholar]
  13. Shalet S. M., Beardwell C. G., Twomey J. A., Jones P. H., Pearson D. Endocrine function following the treatment of acute leukemia in childhood. J Pediatr. 1977 Jun;90(6):920–923. doi: 10.1016/s0022-3476(77)80559-3. [DOI] [PubMed] [Google Scholar]
  14. Siris E. S., Leventhal B. G., Vaitukaitis J. L. Effects of childhood leukemia and chemotherapy on puberty and reproductive function in girls. N Engl J Med. 1976 May 20;294(21):1143–1146. doi: 10.1056/NEJM197605202942102. [DOI] [PubMed] [Google Scholar]
  15. Tan B. C., Kunaratnam N. Hypopituitary dwarfism following radiotherapy for nasopharyngeal carcinoma. Clin Radiol. 1966 Jul;17(3):302–304. doi: 10.1016/s0009-9260(66)80043-0. [DOI] [PubMed] [Google Scholar]

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