Abstract
Cord IgM values were determined in small-for-gestational-age infants born at Hammersmith Hospital during a 5 1/2-year period. 121 (12.5%) infants had levels more than 0.2 g/l; in 92 these were between 0.21 and 0.3 g/l. In only 18 (14.8%) was a level of 0.4 g/l exceeded, and 5 proved cases of intrauterine infection--rubella (2), syphilis (2), and toxoplasmosis (1)--were in this group. The factor most often associated with cord IgM more than 0.4 g/l was prolonged rupture of the membranes. There was an increased incidence of blood group B among the mothers, probably reflecting the greater number of nonCaucasian women giving birth to small-for-gestational-age infants. Determination of cord IgM did not help significantly indiagnosis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alford C. A., Jr Studies on antibody in congenital rubella infections. I. Physicochemical and immunologic investigations of rubella neutralizing antibody. Am J Dis Child. 1965 Oct;110(4):455–463. doi: 10.1001/archpedi.1965.02090030475019. [DOI] [PubMed] [Google Scholar]
- Alford C. A., Schaefer J., Blankenship W. J., Straumfjord J. V., Cassady G. A correlative immunologic, microbiologic and clinical approach to the diagnosis of acute and chronic infections in newborn infants. N Engl J Med. 1967 Aug 31;277(9):437–449. doi: 10.1056/NEJM196708312770901. [DOI] [PubMed] [Google Scholar]
- Habel A. H., Sandor G. S., Conn N. K., McCrae W. M. Premature rupture of membranes and effects of prophylactic antibiotics. Arch Dis Child. 1972 Jun;47(253):401–404. doi: 10.1136/adc.47.253.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hardy J. B. The Johns Hopkins collaborative perinatal project. I. Cord serum immunoglobulin levels and long-range fetal outcome. Johns Hopkins Med J. 1971 Jun;128(6):297–305. [PubMed] [Google Scholar]
- Lechtig A., Mata L. J. Cord IgM levels in Latin American neonates. J Pediatr. 1971 May;78(5):909–910. doi: 10.1016/s0022-3476(71)80376-1. [DOI] [PubMed] [Google Scholar]
- Mellits E. D. Relationships between cord serum immunoglobulin levels and later abnormalities. Is neonatal screening for IgM a worth-while procedure? Johns Hopkins Med J. 1971 Jun;128(6):306–317. [PubMed] [Google Scholar]
- Naeye R. L., Blanc W. A. Relation of poverty and race to antenatal infection. N Engl J Med. 1970 Sep 10;283(11):555–560. doi: 10.1056/NEJM197009102831102. [DOI] [PubMed] [Google Scholar]
- Papadatos C., Alexiou D., Papaevangelou G., Petropoulos H., Mendris J. Serum levels of immune globulins in postmaturity. Arch Dis Child. 1974 Mar;49(3):222–224. doi: 10.1136/adc.49.3.222. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SILVERSTEIN A. M. Congenital syphilis and the timing of immunogenesis in the human foetus. Nature. 1962 Apr 14;194:196–197. doi: 10.1038/194196a0. [DOI] [PubMed] [Google Scholar]
- Sever J. L. Immunoglobulin determinations for the detection of perinatal infections. J Pediatr. 1969 Dec;75(6):1111–1115. doi: 10.1016/s0022-3476(69)80365-3. [DOI] [PubMed] [Google Scholar]
- Stern H., Tucker S. M. Prospective study of cytomegalovirus infection in pregnancy. Br Med J. 1973 May 5;2(5861):268–270. doi: 10.1136/bmj.2.5861.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thomson A. M., Billewicz W. Z., Hytten F. E. The assessment of fetal growth. J Obstet Gynaecol Br Commonw. 1968 Sep;75(9):903–916. doi: 10.1111/j.1471-0528.1968.tb01615.x. [DOI] [PubMed] [Google Scholar]
- Yeager A. S. Variation of cord IgM level with birth weight. Pediatrics. 1973 Apr;51(4):616–619. [PubMed] [Google Scholar]