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. 1979 Apr;54(4):317–319. doi: 10.1136/adc.54.4.317

Fetal growth and parental consanguinity

J R Sibert, Malati Jadhav, S G Inbaraj
PMCID: PMC1545300  PMID: 572202

Abstract

Anthropometric measurements made on 322 newborn infants in South India were related to parental consanguinity. Uncle-niece and first-cousin marriages were common and the average coefficient of inbreeding was as high as 0·0329. The measurements (weight, length, head circumference, and triceps and subscapular skinfold thicknesses) of the uncle-niece groups (52 infants) were smaller than those of the first-cousin group (61 infants) which in turn were smaller than the nonconsanguineous group (196 infants). Statistical significance (P<0·01) was only recorded between the weights of the three groups (means 2650·4, 2794·1, and 2833·8 g) and between the lengths of the uncle-niece group and the nonconsanguineous group (means 46·92 and 47·79 cm). There were no social class or residential differences between the groups. We conclude that there are likely to be recessive genes present in the population, slightly retarding fetal growth.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. MORTON N. E. Empirical risks in consanguineous marriages: birth weight, gestation time, and measurements of infants. Am J Hum Genet. 1958 Sep;10(3):344–349. [PMC free article] [PubMed] [Google Scholar]
  2. Oakley J. R., Parsons R. J., Whitelaw A. G. Standards for skinfold thickness in British newborn infants. Arch Dis Child. 1977 Apr;52(4):287–290. doi: 10.1136/adc.52.4.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Parkin J. M., Hey E. N., Clowes J. S. Rapid assessment of gestational age at birth. Arch Dis Child. 1976 Apr;51(4):259–263. doi: 10.1136/adc.51.4.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Rao P. S., Inbaraj S. G. Inbreeding effects on human reproduction in Tamil Nadu of South India. Ann Hum Genet. 1977 Jul;41(1):87–98. doi: 10.1111/j.1469-1809.1977.tb01964.x. [DOI] [PubMed] [Google Scholar]
  5. SCHORK M. A. THE EFFECTS OF INBREEDING ON GROWTH. Am J Hum Genet. 1964 Sep;16:292–300. [PMC free article] [PubMed] [Google Scholar]
  6. Sibert J. R., Jadhav M., Inbaraj S. G. Maternal and fetal nutrition in south India. Br Med J. 1978 Jun 10;1(6126):1517–1518. doi: 10.1136/bmj.1.6126.1517. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Slatis H. M., Hoene R. E. The Effect of Consanguinity on the Distribution of Continuously Variable-Characteristics. Am J Hum Genet. 1961 Mar;13(1 Pt 1):28–31. [PMC free article] [PubMed] [Google Scholar]

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