Abstract
A 12-year-old boy developed renal wasting of magnesium, calcium, and potassium, with secondary hypomagnesaemia, hypocalcaemia, and hypokalaaemia (without hyperaldosteronism) after treatment with 14 400 mg gentamicin over 4 months. Gentamicin should not be given for prolonged courses if less toxic antibiotics are suitable. If it used, plasma magnesium, calcium, and potassium levels should be monitored during and after treatment.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bar R. S., Wilson H. E., Mazzaferri E. L. Hypomagnesemic hypocalcemia secondary to renal magnesium wasting. Ann Intern Med. 1975 May;82(5):646–649. doi: 10.7326/0003-4819-82-5-646. [DOI] [PubMed] [Google Scholar]
- Holmes A. M., Hesling C. M., Wilson T. M. Drug-induced secondary hyperaldosteronism in patients with pulmonary tuberculosis. Q J Med. 1970 Apr;39(154):299–315. [PubMed] [Google Scholar]
- Kahlmeter G., Kamme G. Letter: Prolonged excretion of gentamicin in a patient with umimpaired renal function. Lancet. 1975 Feb 1;1(7901):286–286. doi: 10.1016/s0140-6736(75)91197-6. [DOI] [PubMed] [Google Scholar]
- Luft F. C., Patel V., Yum M. N., Patel B., Kleit S. A. Experimental aminoglycoside nephrotoxicity. J Lab Clin Med. 1975 Aug;86(2):213–220. [PubMed] [Google Scholar]
- Rude R. K., Oldham S. B., Singer F. R. Functional hypoparathyroidism and parathyroid hormone end-organ resistance in human magnesium deficiency. Clin Endocrinol (Oxf) 1976 May;5(3):209–224. doi: 10.1111/j.1365-2265.1976.tb01947.x. [DOI] [PubMed] [Google Scholar]
- Schentag J. J., Jusko W. J. Gentamicin persistence in the body. Lancet. 1977 Feb 26;1(8009):486–486. doi: 10.1016/s0140-6736(77)91973-0. [DOI] [PubMed] [Google Scholar]
- Shils M. E. Experimental human magnesium depletion. Medicine (Baltimore) 1969 Jan;48(1):61–85. doi: 10.1097/00005792-196901000-00003. [DOI] [PubMed] [Google Scholar]