Abstract
A 5-week-old breast-fed girl presented unconscious and convulsing with heavily blood-stained CSF under increased pressure. This was associated with oozing from venepuncture sites, a grossly prolonged prothrombin time, and a raised platelet count. The prothrombin time became normal 18 hours after she had been given parenteral vitamin K and a transfusion of fresh plasma and red cells, but the thrombocytosis persisted. A moderate communicating hydrocephalus also remained and was treated, and one year later health and development appeared normal. The thrombocytosis resolved after a few weeks and has not recurred.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Addiego J. E., Jr, Mentzer W. C., Jr, Dallman P. R. Thrombocytosis in infants and children. J Pediatr. 1974 Dec;85(6):805–807. doi: 10.1016/s0022-3476(74)80345-8. [DOI] [PubMed] [Google Scholar]
- Cooper N. A., Lynch M. A. Delayed haemorrhagic disease of the newborn with extradural haematoma. Br Med J. 1979 Jan 20;1(6157):164–165. doi: 10.1136/bmj.1.6157.164. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Huttenlocher P. R., Smith D. B. Acute infantile hemiplegia associated with thrombocytosis. Dev Med Child Neurol. 1968 Oct;10(5):621–625. doi: 10.1111/j.1469-8749.1968.tb02946.x. [DOI] [PubMed] [Google Scholar]
- Nammacher M. A., Willemin M., Hartmann J. R., Gaston L. W. Vitamin K deficiency in infants beyond the neonatal period. J Pediatr. 1970 Apr;76(4):549–554. doi: 10.1016/s0022-3476(70)80404-8. [DOI] [PubMed] [Google Scholar]
- Sanyal S. K., Yules R. B., Eidelman A. I., Talner N. W. Thrombocytosis, central nervous system disease, and myocardial infarction pattern in infancy. Pediatrics. 1966 Oct;38(4):629–636. [PubMed] [Google Scholar]