Abstract
In a hospital study rotavirus was identified in 51% of 152 children with diarrhoea. These patients showed a clinical pattern that was distinct from patients in whom the diarrhoea was associated with bacteria, other viruses, or no pathogens. A respiratory illness was described in 66% of rotavirus patients and usually preceded the gastrointestinal symptoms. Vomiting lasted between one and 3 days and was curtailed by substituting the normal diet with clear fluids. Watery diarrhoes continued for 4 or 5 days, even when rehydration was by the intravenous rather than the oral route. Prolonged diarrhoea was rare. Most children infected with rotavirus were under 2 years of age, but dehydration was most severe in infants aged between 12 and 18 months. A clinician can thus recognise the rotavirus syndrome and expect spontaneous recovery if adequate rehydration is maintained for a critical few days.
Full text
PDF







Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Albrey M. B., Murphy A. M. Rotaviruses and acute gastroenteritis of infants and children. Med J Aust. 1976 Jan 24;1(4):82–85. doi: 10.5694/j.1326-5377.1976.tb111890.x. [DOI] [PubMed] [Google Scholar]
- Bishop R. F., Davidson G. P., Holmes I. H., Ruck B. J. Detection of a new virus by electron microscopy of faecal extracts from children with acute gastroenteritis. Lancet. 1974 Feb 2;1(7849):149–151. doi: 10.1016/s0140-6736(74)92440-4. [DOI] [PubMed] [Google Scholar]
- Bullen J. J. Human milk and gut infection in the newborn. Br J Hosp Med. 1977 Sep;18(3):220–231. [PubMed] [Google Scholar]
- Carr M. E., McKendrick G. D., Spyridakis T. The clinical features of infantile gastroenteritis due to rotavirus. Scand J Infect Dis. 1976;8(4):241–243. doi: 10.3109/inf.1976.8.issue-4.04. [DOI] [PubMed] [Google Scholar]
- Coles E. C., Cotter S., Valman H. B. Increasing prevalence of breast-feeding. Br Med J. 1978 Oct 21;2(6145):1122–1122. doi: 10.1136/bmj.2.6145.1122. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davidson G. P., Bishop R. F., Townley R. R., Holmes I. H. Importance of a new virus in acute sporadic enteritis in children. Lancet. 1975 Feb 1;1(7901):242–246. doi: 10.1016/s0140-6736(75)91140-x. [DOI] [PubMed] [Google Scholar]
- DuPont H. L., Portnoy B. L., Conklin R. H. Viral agents and diarrheal illness. Annu Rev Med. 1977;28:167–177. doi: 10.1146/annurev.me.28.020177.001123. [DOI] [PubMed] [Google Scholar]
- Flewett T. H., Davies H., Bryden A. S., Robertson M. J. Diagnostic electron microscopy of faeces. II. Acute gastroenteritis associated with reovirus-like particles. J Clin Pathol. 1974 Aug;27(8):608–614. doi: 10.1136/jcp.27.8.608. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Flewett T. H. Implications of recent virological researches. Ciba Found Symp. 1976;(42):237–250. doi: 10.1002/9780470720240.ch14. [DOI] [PubMed] [Google Scholar]
- Fonteyne J., Zissis G., Lambert J. P. Recurrent rotavirus gastroenteritis. Lancet. 1978 May 6;1(8071):983–983. doi: 10.1016/s0140-6736(78)90263-5. [DOI] [PubMed] [Google Scholar]
- Gomez-Barreto J., Palmer E. L., Nahmias A. J., Hatch M. H. Acute enteritis associated with reovirus-like agents. JAMA. 1976 Apr 26;235(17):1857–1860. [PubMed] [Google Scholar]
- Gust I. D., Pringle R. C., Barnes G. L., Davidson G. P., Bishop R. F. Complement-fixing antibody response to rotavirus infection. J Clin Microbiol. 1977 Feb;5(2):125–130. doi: 10.1128/jcm.5.2.125-130.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kapikian A. Z., Cline W. L., Mebus C. A., Wyatt R. G., Kalica A. R., James H. D., Jr, VanKirk D., Chanock R. M. New complement-fixation test for the human reovirus-like agent of infantile gastroenteritis. Nebraska calf diarrhea virus used as antigen. Lancet. 1975 May 10;1(7915):1056–1061. doi: 10.1016/s0140-6736(75)91827-9. [DOI] [PubMed] [Google Scholar]
- Kapikian A. Z., Kim H. W., Wyatt R. G., Cline W. L., Arrobio J. O., Brandt C. D., Rodriguez W. J., Sack D. A., Chanock R. M., Parrott R. H. Human reovirus-like agent as the major pathogen associated with "winter" gastroenteritis in hospitalized infants and young children. N Engl J Med. 1976 Apr 29;294(18):965–972. doi: 10.1056/NEJM197604292941801. [DOI] [PubMed] [Google Scholar]
- Konno T., Suzuki H., Imai A., Ishida N. Reovirus-like agent in acute epidemic gastroenteritis in Japanese infants: fecal shedding and serologic response. J Infect Dis. 1977 Feb;135(2):259–266. doi: 10.1093/infdis/135.2.259. [DOI] [PubMed] [Google Scholar]
- Madeley C. R., Cosgrove B. P., Bell E. J., Fallon R. J. Stool viruses in babies in Glasgow. I. Hospital admissions with diarrhoea. J Hyg (Lond) 1977 Apr;78(2):261–273. doi: 10.1017/s0022172400056151. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Murphy A. M., Albrey M. B., Crewe E. B. Rotavirus infections of neonates. Lancet. 1977 Dec 3;2(8049):1149–1150. doi: 10.1016/S0140-6736(77)91538-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pullan C. R., Dellagrammatikas H., Steiner H. Survey of gastroenteritis in children admitted to hospital in Newcastle upon Tyne in 1971-5. Br Med J. 1977 Mar 5;1(6061):619–621. doi: 10.1136/bmj.1.6061.619. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rodriguez W. J., Kim H. W., Arrobio J. O., Brandt C. D., Chanock R. M., Kapikian A. Z., Wyatt R. G., Parrott R. H. Clinical features of acute gastroenteritis associated with human reovirus-like agent in infants and young children. J Pediatr. 1977 Aug;91(2):188–193. doi: 10.1016/S0022-3476(77)80810-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schoub B. D., Greeff A. S., Lecatsas G., Prozesky O. W., Hay I. T., Prinsloo J. G., Ballard R. C. A microbiological investigation of acute summer gastroenteritis in black South African infants. J Hyg (Lond) 1977 Jun;78(3):377–385. doi: 10.1017/s0022172400056278. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shepherd R. W., Truslow S., Walker-Smith J. A., Bird R., Cutting W., Darnell R., Barker C. M. Infantile gastroenteritis: a clinical study of reovirus-like agent infection. Lancet. 1975 Nov 29;2(7944):1082–1084. doi: 10.1016/s0140-6736(75)90446-8. [DOI] [PubMed] [Google Scholar]
- Sinha A. K., Tyrrell D. A. Changes in the clinical pattern of gastrointestinal infections in North West London 1968-70. Br J Clin Pract. 1973 Feb;27(2):45–48. [PubMed] [Google Scholar]
- Skirrow M. B. Campylobacter enteritis: a "new" disease. Br Med J. 1977 Jul 2;2(6078):9–11. doi: 10.1136/bmj.2.6078.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stott E. J., Bell E. J., Eadie M. B., Ross C. A., Grist N. R. A comparative virological study of children in hospital with respiratory and diarrhoeal illnesses. J Hyg (Lond) 1967 Mar;65(1):9–23. doi: 10.1017/s0022172400045484. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tallett S., MacKenzie C., Middleton P., Kerzner B., Hamilton R. Clinical, laboratory, and epidemiologic features of a viral gastroenteritis in infants and children. Pediatrics. 1977 Aug;60(2):217–222. [PubMed] [Google Scholar]
- Thouless M. E., Bryden A. S., Flewett T. H. Rotavirus neutralisation by human milk. Br Med J. 1977 Nov 26;2(6099):1390–1390. doi: 10.1136/bmj.2.6099.1390. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Totterdell B. M., Chrystie I. L., Banatvala J. E. Rotavirus infections in a maternity unit. Arch Dis Child. 1976 Dec;51(12):924–928. doi: 10.1136/adc.51.12.924. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tripp J. H., Wilmers M. J., Wharton B. A. Gastroenteritis: a continuing problem of child health in Britain. Lancet. 1977 Jul 30;2(8031):233–236. doi: 10.1016/s0140-6736(77)92846-x. [DOI] [PubMed] [Google Scholar]
- Walker-Smith J. Rotavirus gastroenteritis. Arch Dis Child. 1978 May;53(5):355–362. doi: 10.1136/adc.53.5.355. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zissis G., Lambert J. P. Different serotypes of human rotaviruses. Lancet. 1978 Jan 7;1(8054):38–39. doi: 10.1016/s0140-6736(78)90380-x. [DOI] [PubMed] [Google Scholar]
