Abstract
24 children in whom coeliac disease had been diagnosed between one and 10 years earlier were re-examined for intestinal loss of iron and activity of the disease. Mild iron deficiency by laboratory criteria and by response to iron medication was common. The children with biopsy evidence of flat mucosa or intraepithelial lymphocytosis had a greater iron loss in their stools than those patients with normal, or almost normal, histology. The data suggest that loss of iron was mainly due to intestinal blood loss rather than to shedding of mucosal cells. We conclude that treatment with iron is indicated in many children with coeliac disease as the increased losses of iron persist for long periods although absorption of iron seems to improve or be negligibly affected.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anand B. S., Callender S. T., Warner G. T. Absorption of inorganic and haemoglobin iron in coeliac disease. Br J Haematol. 1977 Nov;37(3):409–414. doi: 10.1111/j.1365-2141.1977.tb01012.x. [DOI] [PubMed] [Google Scholar]
- BADENOCH J., CALLENDER S. T. Effect of corticosteroids and gluten-free diet on absorption of iron inidiopathic steatorrhoea and coeliac disease. Lancet. 1960 Jan 23;1(7117):192–194. doi: 10.1016/s0140-6736(60)90110-0. [DOI] [PubMed] [Google Scholar]
- Ferguson A., McClure J. P., Townley R. R. Intraepithelial lymphocyte counts in small intestinal biopsies from children with diarrhoea. Acta Paediatr Scand. 1976 Sep;65(5):541–546. doi: 10.1111/j.1651-2227.1976.tb04929.x. [DOI] [PubMed] [Google Scholar]
- Rice E. W., Fenner H. E. Study of the ICSH proposed reference method for serum iron assay: obtaining optically clear filtrates and substitution of ferrozine. Clin Chim Acta. 1974 Jun 28;53(3):391–393. doi: 10.1016/0009-8981(74)90283-6. [DOI] [PubMed] [Google Scholar]
- Shmerling D. H., Zimmerli-Häring S. M. Die floride Zöliakie. Untersuchungsergebnisse bei 88 Patienten zwischen 1963 und 1969. Helv Paediatr Acta. 1971 Dec;26(5):565–584. [PubMed] [Google Scholar]
- Siimes M. A., Addiego J. E., Jr, Dallman P. R. Ferritin in serum: diagnosis of iron deficiency and iron overload in infants and children. Blood. 1974 Apr;43(4):581–590. [PubMed] [Google Scholar]
- Sutton D. R., Stewart J. S., Baird I. M., Coghill N. F. "Free" iron loss in atrophic gastritis, post-gastrectomy states, and adult coeliac disease. Lancet. 1970 Aug 22;2(7669):387–389. doi: 10.1016/s0140-6736(70)90004-8. [DOI] [PubMed] [Google Scholar]
- Visakorpi J. K., Kuitunen P., Savilahti E. Frequency and nature of relapses in children suffering from the malabsorption syndrome with gluten intolerance. Acta Paediatr Scand. 1970 Sep;59(5):481–486. doi: 10.1111/j.1651-2227.1970.tb16795.x. [DOI] [PubMed] [Google Scholar]
- Webb M. G., Taylor M. R., Gatenby P. B. Iron absorption in coeliac disease of childhood and adolescence. Br Med J. 1967 Apr 15;2(5545):151–152. doi: 10.1136/bmj.2.5545.151. [DOI] [PMC free article] [PubMed] [Google Scholar]
