Abstract
In 3 cases of acrodermatitis enteropathica duodenal biopsy performed at the outset of treatment showed a similar abnormality of the intestinal mucosa. Further biopsies taken during treatment showed progressive improvement of the intestinal mucosa with subsequent complete restoration of the normal cellular and villous pattern. The initial treatment was with expressed human breast milk and oral di-iodohydroxyquinoline. The latter was continued alone and later replaced by zinc sulphate. Changes in the intestinal epithelial cells and inflammatory cell infiltration of the lamina propria still detectable on di-iodohydroxyquinoline therapy reverted to normal with oral zinc.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Hermos J. A., Adams W. H., Liu Y. K., Sullivan L. W., Trier J. S. Mucosa of the small intestine in folate-deficient alcoholics. Ann Intern Med. 1972 Jun;76(6):957–965. doi: 10.7326/0003-4819-76-6-957. [DOI] [PubMed] [Google Scholar]
- MARGILETH A. M. Acrodermatitis enteropathica. Case report and review of literature. Am J Dis Child. 1963 Mar;105:285–291. [PubMed] [Google Scholar]
- MOYNAHAN E. J. Acrodermatitis enteropathica. Proc R Soc Med. 1962 Mar;55:240–240. [PMC free article] [PubMed] [Google Scholar]
- Moynahan E. J. Letter: Acrodermatitis enteropathica: a lethal inherited human zinc-deficiency disorder. Lancet. 1974 Aug 17;2(7877):399–400. doi: 10.1016/s0140-6736(74)91772-3. [DOI] [PubMed] [Google Scholar]
- Neldner K. H., Hagler L., Wise W. R., Stifel F. B., Lufkin E. G., Herman R. H. Acrodermatitis enteropathica. A clinical and biochemical survey. Arch Dermatol. 1974 Nov;110(5):711–721. doi: 10.1001/archderm.110.5.711. [DOI] [PubMed] [Google Scholar]
- Townley R. R., Barnes G. L. Intestinal biopsy in childhood. Arch Dis Child. 1973 Jun;48(6):480–482. doi: 10.1136/adc.48.6.480. [DOI] [PMC free article] [PubMed] [Google Scholar]