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. 1976 Jul;51(7):507–511. doi: 10.1136/adc.51.7.507

Association of cystic fibrosis with allergy.

J O Warner, B W Taylor, A P Norman, J F Soothill
PMCID: PMC1546044  PMID: 962361

Abstract

Immediate skin hypersensitivity to various inhalant allergens was present in 59% of 123 children with cystic fibrosis (CF), a much higher percentage than in the general population. This is consistent with the idea that atopy arises as a result of impaired handling of antigen at mucosal surfaces. The allergic CF children had more chest infections, a worse chest x-ray appearance, and lower peak expiratory flow rates. Allergic diseases were also frequent in the CF obligate heterozygotes (32% of mothers and 26% of fathers). It is suggested that the heterozygotes may also have a mucosal abnormality resulting in defective antigen handling.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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