Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1976 Aug;51(8):618–623. doi: 10.1136/adc.51.8.618

Arthrogryposis multiplex congenita. Search for prenatal factors in 66 sporadic cases.

R Wynne-Davies, G C Lloyd-Roberts
PMCID: PMC1546116  PMID: 962372

Abstract

In a family and epidemiological survey of 66 cases of arthrogryposis multiplex congenita all cases were found to be sporadic and no family association with clubfoot, congenital dislocation of the hip, or hereditary neuromuscular disease was found. The mothers were significantly older than average. Oligohydramnios was noted in only one-third of cases but many other complications of pregnancy, including probable attempts at abortion, had occurred. It is likely that most cases of arthrogryposis are nongenetic and result from a defective intrauterine environment, whether hormonal, vascular, mechanical, or possibly infective.

Full text

PDF
618

Images in this article

619FIG.
on p.619

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amick L. D., Johnson W. W., Smith H. L. Electromyographic and histopathologic correlations in arthrogryposis. Arch Neurol. 1967 May;16(5):512–523. doi: 10.1001/archneur.1967.00470230064009. [DOI] [PubMed] [Google Scholar]
  2. BANKER B. Q., VICTOR M., ADAMS R. D. Arthrogryposis multiplex due to congenital muscular dystrophy. Brain. 1957 Sep;80(3):319–334. doi: 10.1093/brain/80.3.319. [DOI] [PubMed] [Google Scholar]
  3. BROWNE D. Congenital deformities of mechanical origin. Arch Dis Child. 1955 Feb;30(149):37–41. doi: 10.1136/adc.30.149.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bharucha E. P., Pandya S. S., Dastur D. K. Arthrogryposis multiplex congenita. I. Clinical and electromyographic aspects. J Neurol Neurosurg Psychiatry. 1972 Aug;35(4):425–434. doi: 10.1136/jnnp.35.4.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DRACHMAN D. B., BANKER B. Q. Arthrogryposis multiplex congenita. Case due to disease of the anterior horn cells. Arch Neurol. 1961 Jul;5:77–93. doi: 10.1001/archneur.1961.00450130079010. [DOI] [PubMed] [Google Scholar]
  6. DRACHMAN D. B., COULOMBRE A. J. Experimental clubfoot and arthrogryposis multiplex congenita. Lancet. 1962 Sep 15;2(7255):523–526. doi: 10.1016/s0140-6736(62)90399-9. [DOI] [PubMed] [Google Scholar]
  7. Dastur D. K., Razzak Z. A., Bharucha E. P. Arthrogryposis multiplex congenita. 2. Muscle pathology and pathogenesis. J Neurol Neurosurg Psychiatry. 1972 Aug;35(4):435–450. doi: 10.1136/jnnp.35.4.435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. García Villanueva G. R. Arthrogryposis multipla congenita. An electromyographic study. Electroencephalogr Clin Neurophysiol. 1968 Apr;24(4):389–389. [PubMed] [Google Scholar]
  9. Gibson D. A., Urs N. D. Arthrogryposis multiplex congenita. J Bone Joint Surg Br. 1970 Aug;52(3):483–493. [PubMed] [Google Scholar]
  10. Ionasescu V., Zellweger H., Filer L. J., Jr, Conway T. W. Increased collagen synthesis in arthrogryposis multiplex congenita. Arch Neurol. 1970 Aug;23(2):128–136. doi: 10.1001/archneur.1970.00480260034005. [DOI] [PubMed] [Google Scholar]
  11. Jago R. H. Arthrogryposis following treatment of maternal tetanus with muscle relaxants. Arch Dis Child. 1970 Apr;45(240):277–279. doi: 10.1136/adc.45.240.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. KANOF A., ARONSON S. M., VOLK B. W. Arthrogryposis; a clinical and pathological study of three cases. Pediatrics. 1956 Apr;17(4):532–540. [PubMed] [Google Scholar]
  13. Laitinen O., Hirvensalo M. Arthrogryposis multiplex congenita. Ann Paediatr Fenn. 1966;12(2):133–138. [PubMed] [Google Scholar]
  14. Lamy M., Jammet M. L., Ajjan N. Arthrogrypose ou syndrome arthrogryposique? A propos de dix observations. Ann Pediatr (Paris) 1965 Oct 20;12(10):591–602. [PubMed] [Google Scholar]
  15. MEAD N. G., LITHGOW W. C., SWEENEY H. J. Arthrogryposis multiplex congenita. J Bone Joint Surg Am. 1958 Dec;40-A(6):1285–1309. [PubMed] [Google Scholar]
  16. PEARSON C. M., FOWLER W. G., Jr Hereditary non-progressive muscular dystrophy inducing arthrogryposis syndrome. Brain. 1963 Mar;86:75–88. doi: 10.1093/brain/86.1.75. [DOI] [PubMed] [Google Scholar]
  17. Vestermark B. Arthrogryposis multiplex congenita. A case of neurogenic origin. Acta Paediatr Scand. 1966 Jan;55(1):117–120. doi: 10.1111/j.1651-2227.1966.tb15216.x. [DOI] [PubMed] [Google Scholar]
  18. Williams P. F. The elbow in arthrogryposis. J Bone Joint Surg Br. 1973 Nov;55(4):834–840. [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES