Abstract
A quantitative morphological assessment was carried out of the cellularity and staining properties of the cells of the layers of the human cerebellar cortex, both in the normal child and in 41 children suffering from a series of disorders including mental retardation. A computerized image analyser and highly standardized procedures were used. All of the cases of mental retardation and some cases with congenital cardiac anomalies showed abnormal cell concentrations and staining properties. 3 cases of 'cot death' also showed abnormal results. These findings are presented as a new measurable aspect of brain disease, and as a indication for further study.
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Selected References
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- Cole M., Bond C. P. Recent advances in automatic image analysis using a television system. J Microsc. 1972 Aug;96(1):89–96. doi: 10.1111/j.1365-2818.1972.tb03747.x. [DOI] [PubMed] [Google Scholar]
- Dobbing J., Hopewell J. W., Lynch A. Vulnerability of developing brain. VII. Permanent deficit of neurons in cerebral and cerebellar cortex following early mild undernutrition. Exp Neurol. 1971 Sep;32(3):439–447. doi: 10.1016/0014-4886(71)90010-0. [DOI] [PubMed] [Google Scholar]
- Emery J. L., Swift P. G., Worthy E. Hypernatraemia and uraemia in unexpected death in infancy. Arch Dis Child. 1974 Sep;49(9):686–692. doi: 10.1136/adc.49.9.686. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gadsdon D. R., Emery J. L. Fatty change in the brain in perinatal and unexpected death. Arch Dis Child. 1976 Jan;51(1):42–48. doi: 10.1136/adc.51.1.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUNTER D., RUSSELL D. S. Focal cerebellar and cerebellar atrophy in a human subject due to organic mercury compounds. J Neurol Neurosurg Psychiatry. 1954 Nov;17(4):235–241. doi: 10.1136/jnnp.17.4.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Herndon R. M. Thiophen induced granule cell necrosis in the rat cerebellum. An electron microscopic study. Exp Brain Res. 1968;6(1):49–68. doi: 10.1007/BF00235446. [DOI] [PubMed] [Google Scholar]
- Hirono I., Shibuya C., Hayashi K. Induction of a cerebellar disorder with cycasin in newborn mice and hamsters. Proc Soc Exp Biol Med. 1969 Jun;131(2):593–599. doi: 10.3181/00379727-131-33933. [DOI] [PubMed] [Google Scholar]
- KOKENGE R., KUTT H., MCDOWELL F. NEUROLOGICAL SEQUELAE FOLLOWING DILANTIN OVERDOSE IN A PATIENT AND IN EXPERIMENTAL ANIMALS. Neurology. 1965 Sep;15:823–829. doi: 10.1212/wnl.15.9.823. [DOI] [PubMed] [Google Scholar]
- Shimada M., Langman J. Repair of the external granular layer of the hamster cerebellum after prenatal and postnatal administration of methylazoxymethanol. Teratology. 1970 May;3(2):119–133. doi: 10.1002/tera.1420030204. [DOI] [PubMed] [Google Scholar]