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. 1976 Sep;51(9):680–685. doi: 10.1136/adc.51.9.680

Role of chronic hepatitis in development of thalassaemic liver disease.

G Masera, G Jean, G Gazzola, M Novakova
PMCID: PMC1546247  PMID: 793538

Abstract

Liver function and the presence of HBsAg and anti-HBsAg were studied in 90 hypertransfused thalassaemic children. Increased serum transaminases were found in 62 patients, and persisted from more than 6 months in 45 cases. Liver biopsy in this latter group led to a diagnosis of 14 cases of chronic persistent hepatitis, 9 cases of aggressive hepatitis, and 3 cases of hepatic fibrosis. In Italy thalassaemic children undergoing hypertransfusion therapy frequently encounter SH virus infection, with a consequent hepatitis that is generally anicteric and unrecognized unless systematically sought. In a liver already stressed by the concomitant iron overload, hepatitis infection might thus play a key role in the evolution of cirrhosis which frequently affects thalassaemics.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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