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. 1977 Mar;52(3):176–182. doi: 10.1136/adc.52.3.176

Neurological sequelae in children surviving mechanical ventilation in the neonatal period.

K J Marriage, P A Davies
PMCID: PMC1546263  PMID: 848995

Abstract

The incidence of mental defect, visual and hearing disability, major neurological handicap, and such minor neurological handicap as can be detected on examination at 2--9 years without formal intelligence testing, is presented among survivors of neonatal mechanical ventilation at Hammersmith Hospital between the years 1966--1973 inclusive. 77(21%) of 367 children survived, over three-quarters of them being born elsewhere. 3 died before the age of 6 months, 2 suddenly and unexpectedly at home, the third accidentally. 1 child was lost to follow up. 11 (15%) of the remaining 73 children had neurological sequelae as defined. In two-thirds this was moderate to severe. Spastic diplegia may no longer be the commonest form of cerebral palsy among those of low birthweight, particularly those surviving severe neonatal illness.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armstrong D., Norman M. G. Periventricular leucomalacia in neonates. Complications and sequelae. Arch Dis Child. 1974 May;49(5):367–375. doi: 10.1136/adc.49.5.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brand M. M., Bignami A. The effects of chronic hypoxia on the neonatal and infantile brain. A neuropathological study of five premature infants with the respiratory distress syndrome treated by prolonged artificial ventilation. Brain. 1969;92(2):233–254. doi: 10.1093/brain/92.2.233. [DOI] [PubMed] [Google Scholar]
  3. Brown J. K., Cockburn F., Forfar J. O., Marshall R. L., Stephen G. W. Problems in the management of assisted ventilation in the newborn and follow-up of treated cases. Br J Anaesth. 1973 Jul;45(Suppl):808–817. [PubMed] [Google Scholar]
  4. Davies P. A., Tizard J. P. Very low birthweight and subsequent neurological defect (with special reference to spastic diplegia). Dev Med Child Neurol. 1975 Feb;17(1):3–17. doi: 10.1111/j.1469-8749.1975.tb04951.x. [DOI] [PubMed] [Google Scholar]
  5. Dinwiddie R., Mellor D. H., Donaldson H. C., Tunstall M. E., Russell G. Quality of survival after artificial ventilation of the newborn. Arch Dis Child. 1974 Sep;49(9):703–710. doi: 10.1136/adc.49.9.703. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fitzhardinge P. M., Pape P., Arstikaitis M., Boyle M., Ashby S., Rowley A., Netley C., Swyer P. R. Mechanical ventilation of infants of less than 1,501 gm birth weight: Health, growth, and neurologic sequelae. J Pediatr. 1976 Apr;88(4 Pt 1):531–541. doi: 10.1016/s0022-3476(76)80001-7. [DOI] [PubMed] [Google Scholar]
  7. Francis-Williams J., Davies P. A. Very low birthweight and later intelligence. Dev Med Child Neurol. 1974 Dec;16(6):709–728. doi: 10.1111/j.1469-8749.1974.tb03392.x. [DOI] [PubMed] [Google Scholar]
  8. Frankenburg W. K., Dodds J. B. The Denver developmental screening test. J Pediatr. 1967 Aug;71(2):181–191. doi: 10.1016/s0022-3476(67)80070-2. [DOI] [PubMed] [Google Scholar]
  9. Gregory G. A., Kitterman J. A., Phibbs R. H., Tooley W. H., Hamilton W. K. Treatment of the idiopathic respiratory-distress syndrome with continuous positive airway pressure. N Engl J Med. 1971 Jun 17;284(24):1333–1340. doi: 10.1056/NEJM197106172842401. [DOI] [PubMed] [Google Scholar]
  10. Grunnet M. L., Curless R. G., Bray P. F., Jung A. L. Brain changes in newborns from an intensive care unit. Dev Med Child Neurol. 1974 Jun;16(3):320–328. doi: 10.1111/j.1469-8749.1974.tb03342.x. [DOI] [PubMed] [Google Scholar]
  11. Hagberg G., Hagberg G., Olow I. The changing panorama of cerebral palsy in Sweden 1954-1970. II. Analysis of the various syndromes. Acta Paediatr Scand. 1975 Mar;64(2):193–200. doi: 10.1111/j.1651-2227.1975.tb03821.x. [DOI] [PubMed] [Google Scholar]
  12. Harrod J. R., L'Heureux P., Wangensteen O. D., Hunt C. E. Long-term follow-up of severe respiratory distress syndrome treated with IPPB. J Pediatr. 1974 Feb;84(2):277–285. doi: 10.1016/s0022-3476(74)80623-2. [DOI] [PubMed] [Google Scholar]
  13. Hof R., Weisser K. Spätfolgen nach intermittierender Uberdruckbeatmung bei schwerem idiophatischem "Respiratory Distress Syndrome". Schweiz Med Wochenschr. 1969 Dec 20;99(51):1853–1861. [PubMed] [Google Scholar]
  14. Johnson J. D., Malachowski N. C., Grobstein R., Welsh D., Daily W. J., Sunshine P. Prognosis of children surviving with the aid of mechanical ventilation in the newborn period. J Pediatr. 1974 Feb;84(2):272–276. doi: 10.1016/s0022-3476(74)80622-0. [DOI] [PubMed] [Google Scholar]
  15. Murdock A. I., Linsao L., Reid M. M., Sutton M. D., Tilak K. S., Ulan O. A., Swyer P. R. Mechanical ventilation in the respiratory distress syndrome: a controlled trial. Arch Dis Child. 1970 Oct;45(243):624–633. doi: 10.1136/adc.45.243.624. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Reid D. H., Tunstall M. E., Mitchell R. G. A controlled trial of artificial respiration in the respiratory-distress syndrome of the newborn. Lancet. 1967 Mar 11;1(7489):532–533. doi: 10.1016/s0140-6736(67)92112-5. [DOI] [PubMed] [Google Scholar]
  17. Reynolds E. O. Management of hyaline membrane disease. Br Med Bull. 1975 Jan;31(1):18–24. doi: 10.1093/oxfordjournals.bmb.a071235. [DOI] [PubMed] [Google Scholar]
  18. Reynolds E. O., Taghizadeh A. Improved prognosis of infants mechanically ventilated for hyaline membrane disease. Arch Dis Child. 1974 Jul;49(7):505–515. doi: 10.1136/adc.49.7.505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Schneider H., Schachinger H., Dicht R. Telencephalic leucoencephalopathy in premature infants dying after prolonged artificial respiration. Report on 6 cases. Neuropadiatrie. 1975 Nov;6(4):347–362. doi: 10.1055/s-0028-1091676. [DOI] [PubMed] [Google Scholar]
  20. Smith J. F., Reynolds E. O., Taghizadeh A. Brain maturation and damage in infants dying from chronic pulmonary insufficiency in the postneonatal period. Arch Dis Child. 1974 May;49(5):359–366. doi: 10.1136/adc.49.5.359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Storrs C. N., Taylor M. R. Transport of sick newborn babies. Br Med J. 1970 Aug 8;3(5718):328–332. doi: 10.1136/bmj.3.5718.328. [DOI] [PMC free article] [PubMed] [Google Scholar]

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