Abstract
Asians living in Pakistan have serum 25-hydroxycholecalciferol concentrations which are well within the normal range and significantly higher than in Asians resident in Britain. Clearly, Asians can maintain an adequate vitamin D state given an abundant supply of ultraviolet light, and the expression of vitamin D deficiency is an environmental and not a genetically determined characteristic. The risk of an Asian developing vitamin D deficiency increases after migration to Britain. The most efficient way to treat this is by supplementation with vitamin D.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Clemens T. L., Adams J. S., Henderson S. L., Holick M. F. Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. Lancet. 1982 Jan 9;1(8263):74–76. doi: 10.1016/s0140-6736(82)90214-8. [DOI] [PubMed] [Google Scholar]
- Dunnigan M. G., McIntosh W. B., Sutherland G. R., Gardee R., Glekin B., Ford J. A., Robertson I. Policy for prevention of Asian rickets in Britain: a preliminary assessment of the Glasgow rickets campaign. Br Med J (Clin Res Ed) 1981 Jan 31;282(6261):357–360. doi: 10.1136/bmj.282.6261.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hodgkin P., Hine P. M., Kay G. H., Lumb G. A., Stanbury S. W. Vitamin-D deficiency in Asians at home and in Britain. Lancet. 1973 Jul;2(7822):167–171. doi: 10.1016/s0140-6736(73)93004-3. [DOI] [PubMed] [Google Scholar]
- Johnson F. S., Mo T., Green A. E. Average latitudinal variation in ultraviolet radiation at the earth's surface. Photochem Photobiol. 1976 Mar;23(3):179–188. doi: 10.1111/j.1751-1097.1976.tb07239.x. [DOI] [PubMed] [Google Scholar]
- Pettifor J. M., Ross F. P., Solomon L. Seasonal variation in serum 25-hydroxycholecalciferol concentrations in elderly South African patients with fractures of femoral neck. Br Med J. 1978 Apr 1;1(6116):826–827. doi: 10.1136/bmj.1.6116.826. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Preece M. A., TomlinsonS, Ribot C. A., Pietrek J., Korn H. T., Davies D. M., Ford J. A., Dunnigan M. G., O'Riordan J. L. Studies of vitamin D deficiency in man. Q J Med. 1975 Oct;44(176):575–589. [PubMed] [Google Scholar]
- Rab S. M. Occult osteomalacia amongst healthy and pregnant women in Pakistan. Lancet. 1976 Dec 4;2(7997):1211–1213. doi: 10.1016/s0140-6736(76)91141-7. [DOI] [PubMed] [Google Scholar]
- Stamp T. C., Walker P. G., Perry W., Jenkins M. V. Nutritional osteomalacia and late rickets in Greater London, 1974--1979: clinical and metabolic studies in 45 patients. Clin Endocrinol Metab. 1980 Mar;9(1):81–105. doi: 10.1016/s0300-595x(80)80022-3. [DOI] [PubMed] [Google Scholar]
- Stephens W. P., Klimiuk P. S., Berry J. L., Mawer E. B. Annual high-dose vitamin D prophylaxis in Asian immigrants. Lancet. 1981 Nov 28;2(8257):1199–1202. doi: 10.1016/s0140-6736(81)91439-2. [DOI] [PubMed] [Google Scholar]
- Stephens W. P., Klimiuk P. S., Warrington S., Taylor J. L., Berry J. L., Mawer E. B. Observations on the natural history of vitamin D deficiency amongst Asian immigrants. Q J Med. 1982 Spring;51(202):171–188. [PubMed] [Google Scholar]
- Stephens W. P., Klimiuk P. S., Warrington S., Taylor J. L., Mawer E. B. Seasonal changes in serum 25-hydroxyvitamin D concentrations among Asian immigrants. Clin Sci (Lond) 1982 Dec;63(6):577–580. doi: 10.1042/cs0630577. [DOI] [PubMed] [Google Scholar]