Abstract
During the decade in which the medical dissolution of gall stones has become feasible several drugs have been introduced but only the two listed in the British National Formulary have been intensively evaluated and shown to be effective--chenodeoxycholic acid and the closely allied ursodeoxycholic acid. The dissolution of gall stones was last reviewed in the "BMF" in 1976, at which stage experience with chenodeoxycholic acid was limited. Since then the indications and potential for this bile acid in treating gall stones have become better understood, and data on the newly introduced ursodeoxycholic acid are being evaluated. Cholesterol, but not pigment, gall stones are amenable to oral dissolution treatment. This review will cover firstly, chenodeoxycholic acid, secondly, ursodeoxycholic acid, then a comparison of the two drugs, an assessment of the place of medical dissolution in the management of gall stones, and, finally, the dissolution of stones in the common bile duct.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Björkstén F., Suoniemi I., Koski V. Neonatal birch-pollen contact and subsequent allergy to birch pollen. Clin Allergy. 1980 Sep;10(5):585–591. doi: 10.1111/j.1365-2222.1980.tb02140.x. [DOI] [PubMed] [Google Scholar]
- Bouchier I. A. Diseases of the alimentary system. Gall stones. Br Med J. 1976 Oct 9;2(6040):870–872. doi: 10.1136/bmj.2.6040.870. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bouchier I. A. The medical treatment of gallstones. Annu Rev Med. 1980;31:59–77. doi: 10.1146/annurev.me.31.020180.000423. [DOI] [PubMed] [Google Scholar]
- Jarrett L. N., Balfour T. W., Bell G. D., Knapp D. R., Rose D. H. Intraductal infusion of mono-octanoin: experience in 24 patients with retained common-duct stones. Lancet. 1981 Jan 10;1(8211):68–70. doi: 10.1016/s0140-6736(81)90003-9. [DOI] [PubMed] [Google Scholar]
- Maton P. N., Iser J. H., Reuben A., Saxton H. M., Murphy G. M., Dowling R. H. Outcome of chenodeoxycholic acid (CDCA) treatment in 125 patients with radiolucent gallstones. Factors influencing efficacy, withdrawal, symptoms and side effects and post-dissolution recurrence. Medicine (Baltimore) 1982 Mar;61(2):86–97. doi: 10.1097/00005792-198203000-00003. [DOI] [PubMed] [Google Scholar]
- Matthew D. J., Taylor B., Norman A. P., Turner M. W. Prevention of eczema. Lancet. 1977 Feb 12;1(8007):321–324. doi: 10.1016/s0140-6736(77)91131-x. [DOI] [PubMed] [Google Scholar]
- OLDFIELD M. C. Mondor's disease. A superficial phlebitis of the breast. Lancet. 1962 May 12;1(7237):994–996. doi: 10.1016/s0140-6736(62)92034-2. [DOI] [PubMed] [Google Scholar]
- Warner J. O., Price J. F. House dust mite sensitivity in childhood asthma. Arch Dis Child. 1978 Sep;53(9):710–713. doi: 10.1136/adc.53.9.710. [DOI] [PMC free article] [PubMed] [Google Scholar]