Abstract
A five year survey of the treatment of patients in the United Kingdom suffering from haemophilia and related disorders was carried out on behalf of the directors of haemophilia centres. The survey showed an increase in the number of patients receiving treatment from the centres, a substantial increase in the total amount of therapeutic materials used, and an increase in the average amount of factor VIII or factor IX used yearly per patient. Home treatment became established for severely affected patients and accounted for roughly half of the total amount of material used. Study of the acquisition of factor VIII or factor IX antibodies (inhibitors) in patients with haemophilia A or haemophilia B showed no increase in antibodies during the survey period, despite the increased use of factor VIII and factor IX concentrates. The occurrence of acute hepatitis in treated patients was also studied and no increased incidence was observed. A near normal median expectation of life in patients with severe haemophilia A was found.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Biggs R. Haemophilia treatment in the United Kingdom from 1969 to 1974. Br J Haematol. 1977 Apr;35(4):487–504. doi: 10.1111/j.1365-2141.1977.tb00615.x. [DOI] [PubMed] [Google Scholar]
- Biggs R. Jaundice and antibodies directed against factors 8 and 9 in patients treated for haemophilia or Christmas disease in the United Kingdom. Br J Haematol. 1974 Mar;26(3):313–329. doi: 10.1111/j.1365-2141.1974.tb00476.x. [DOI] [PubMed] [Google Scholar]
- Biggs R., Spooner R. J. Haemophilia Centre Director's annual statistics for 1975. Br J Haematol. 1977 Jul;36(3):447–449. doi: 10.1111/j.1365-2141.1977.tb00668.x. [DOI] [PubMed] [Google Scholar]
- Biggs R., Spooner R. J. National survey of haemophilia and Christmas disease patients in the United Kingdom. Report on behalf of the Haemophilia Reference Centre directors of the U.K. Lancet. 1978 May 27;1(8074):1143–1144. doi: 10.1016/s0140-6736(78)90313-6. [DOI] [PubMed] [Google Scholar]