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. 1983 Mar 19;286(6369):921–923. doi: 10.1136/bmj.286.6369.921

Oral glucose decreases hepatic extraction of insulin.

O M Gibby, C N Hales
PMCID: PMC1547347  PMID: 6403135

Abstract

Peripheral venous (plasma) insulin and C-peptide concentrations were measured in eight normal subjects given oral or intravenous glucose sufficient to produce similar plasma glucose concentrations. The expected increased insulin response to oral as compared with intravenous glucose was not matched by a comparable increase in C-peptide concentration. The ratio of insulin to C-peptide concentrations doubled 30 minutes after oral glucose was given; no comparable rise was seen with intravenous glucose (p = 0.01). This finding is interpreted as evidence for decreased hepatic extraction of insulin after administration of oral glucose. Such a decrease could account for at least half of the well known difference in peripheral insulin concentrations after administration of oral as compared with intravenous glucose.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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