Abstract
Twenty patients receiving long term diuretic treatment for arterial hypertension (18 patients) or congestive heart failure (two patients) received magnesium supplementation as aspartate hydrochloride 15 mmol/day for six months. Both systolic and diastolic pressures decreased significantly, by a mean of 12/8 mm Hg. No significant changes were recorded in plasma or urinary electrolytes except for magnesium, 24 hour urinary volumes, or body weight after treatment. The effect of magnesium on blood pressure may be direct or through influences on the internal balance of potassium, sodium, and calcium.
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- Addison W. L. The Use of Sodium Chloride, Potassium Chloride, Sodium Bromide, and Potassium Bromide in Cases of Arterial Hypertension which are Amenable to Potassium Chloride. Can Med Assoc J. 1928 Mar;18(3):281–285. [PMC free article] [PubMed] [Google Scholar]
- BORST J. G., BORST-DE GEUS A. Hypertension explained by Starling's theory of circulatory homoeostasis. Lancet. 1963 Mar 30;1(7283):677–682. doi: 10.1016/s0140-6736(63)91443-0. [DOI] [PubMed] [Google Scholar]
- Brown J. J., Lever A. F., Robertson J. I. Pathogenesis of essential hypertension. Lancet. 1976 Jun 5;1(7971):1217–1219. doi: 10.1016/s0140-6736(76)92164-4. [DOI] [PubMed] [Google Scholar]
- CRANSTON W. I., JUEL-JENSEN B. E., SEMMENCE A. M., JONES R. P., FORBES J. A., MUTCH L. M. EFFECTS OF ORAL DIURETICS ON RAISED ARTERIAL PRESSURE. Lancet. 1963 Nov 9;2(7315):966–970. doi: 10.1016/s0140-6736(63)90671-8. [DOI] [PubMed] [Google Scholar]
- Dyckner T., Wester P. O. The relation between extra- and intracellular electrolytes in patients with hypokalemia and/or diuretic treatment. Acta Med Scand. 1978;204(4):269–282. doi: 10.1111/j.0954-6820.1978.tb08438.x. [DOI] [PubMed] [Google Scholar]
- Edmonds C. J., Jasani B. Total-body potassium in hypertension patients during prolonged diuretic therapy. Lancet. 1972 Jul 1;2(7766):8–12. doi: 10.1016/s0140-6736(72)91275-5. [DOI] [PubMed] [Google Scholar]
- Ericsson F., Carlmark B., Eliasson K. Erythrocyte and total body potassium in untreated primary hypertension. Acta Med Scand. 1981;209(6):439–444. doi: 10.1111/j.0954-6820.1981.tb11626.x. [DOI] [PubMed] [Google Scholar]
- Freis E. D. Salt, volume and the prevention of hypertension. Circulation. 1976 Apr;53(4):589–595. doi: 10.1161/01.cir.53.4.589. [DOI] [PubMed] [Google Scholar]
- Henningsen N. C., Ohlsson O., Mattson S., Nosslin B. Whole body measurements of sodium turnover in offspring of patients with sustained essential hypertension. Eur J Nucl Med. 1982;7(5):225–228. doi: 10.1007/BF00256469. [DOI] [PubMed] [Google Scholar]
- Lim P., Jacob E. Magnesium deficiency in patients on long-term diuretic therapy for heart failure. Br Med J. 1972 Sep 9;3(5827):620–622. doi: 10.1136/bmj.3.5827.620. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MacGregor G. A., Smith S. J., Markandu N. D., Banks R. A., Sagnella G. A. Moderate potassium supplementation in essential hypertension. Lancet. 1982 Sep 11;2(8298):567–570. doi: 10.1016/s0140-6736(82)90657-2. [DOI] [PubMed] [Google Scholar]
- Meneely G. R., Battarbee H. D. High sodium-low potassium environment and hypertension. Am J Cardiol. 1976 Nov 23;38(6):768–785. doi: 10.1016/0002-9149(76)90356-8. [DOI] [PubMed] [Google Scholar]
- Petersen B., Schroll M., Christiansen C., Transbol I. Serum and erythrocyte magnesium in normal elderly danish people. Relationship to blood pressure and serum lipids. Acta Med Scand. 1977 Jan;201(1-2):31–34. doi: 10.1111/j.0954-6820.1977.tb15650.x. [DOI] [PubMed] [Google Scholar]
- SKOU J. C. The influence of some cations on an adenosine triphosphatase from peripheral nerves. Biochim Biophys Acta. 1957 Feb;23(2):394–401. doi: 10.1016/0006-3002(57)90343-8. [DOI] [PubMed] [Google Scholar]
- Woodhouse N. J., Doyle F. H., Joplin G. F. Vitamin-D deficiency and primary hyperparathyroidism. Lancet. 1971 Aug 7;2(7719):283–286. doi: 10.1016/s0140-6736(71)91333-x. [DOI] [PubMed] [Google Scholar]