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. 1983 Jul 2;287(6384):12–14. doi: 10.1136/bmj.287.6384.12

Effect of daily oral omeprazole on 24 hour intragastric acidity.

R P Walt, M D Gomes, E C Wood, L H Logan, R E Pounder
PMCID: PMC1548155  PMID: 6407676

Abstract

Twenty four hour intragastric acidity was measured in nine patients with duodenal ulcer before and after one week of treatment with oral omeprazole 30 mg daily, a drug that inhibits gastric secretion by inhibition of parietal cell H+K+ adenosinetriphosphatase (ATPase). Omeprazole virtually eliminated intragastric acidity in all patients: the median 24 hour intragastric pH rose from 1.4 to 5.3 and the mean hourly hydrogen ion activity fell from 38.50 to 1.95 mmol(mEq)/1 (p less than 0.001). This inhibition of 24 hour intragastric acidity is more profound than that previously reported with either cimetidine 1 g daily or ranitidine 300 mg daily.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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