Skip to main content
NCBI home page
British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1983 Aug 27;287(6392):580–583. doi: 10.1136/bmj.287.6392.580

Case-control study of severe pre-eclampsia of early onset.

M P Moore, C W Redman
PMCID: PMC1548969  PMID: 6411232

Abstract

Twenty four women with severe pre-eclampsia diagnosed before 34 weeks' gestation were compared with 48 randomly selected controls matched for age and parity. Subjects were studied in the puerperium using a questionnaire, clinical examination, and review of case records. A history of infertility, headaches (particularly migraine), pre-eclampsia in a previous pregnancy, or a raised serum alpha-fetoprotein concentration at the time of screening for neural tube defect in the index pregnancy were all identified as significant risk factors in the pre-eclamptic women. Maternal age, a history of chronic hypertension or renal disease, or excessive maternal weight were not significantly associated with pre-eclampsia. Almost all the infants of pre-eclamptic women showed retarded growth: 18 were below the 10th centile and only one weighed more than the 25th centile. Four babies died. These observations indicate that pre-eclampsia of early onset may differ from the late onset disease not only in its very high perinatal morbidity and mortality but in its distinctive maternal risk factors.

Full text

PDF
580

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. APPENZELLER O., DAVISON K., MARSHALL J. REFLEX VASOMOTOR ABNORMALITIES IN THE HANDS OF MIGRAINOUS SUBJECTS. J Neurol Neurosurg Psychiatry. 1963 Oct;26:447–450. doi: 10.1136/jnnp.26.5.447. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BILLEWICZ W. Z., KEMSLEY W. F., THOMSON A. M. Indices of adiposity. Br J Prev Soc Med. 1962 Oct;16:183–188. doi: 10.1136/jech.16.4.183. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Baird D. Epidemiological aspects of hypertensive pregnancy. Clin Obstet Gynaecol. 1977 Dec;4(3):531–548. [PubMed] [Google Scholar]
  4. Bulpitt C. J., Dollery C. T., Carne S. Change in symptoms of hypertensive patients after referral to hospital clinic. Br Heart J. 1976 Feb;38(2):121–128. doi: 10.1136/hrt.38.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Coffman J. D., Cohen R. A. Vasospasm--ubiquitous? N Engl J Med. 1981 Mar 26;304(13):780–782. doi: 10.1056/NEJM198103263041311. [DOI] [PubMed] [Google Scholar]
  6. Franchi G., Anselmi B., Michelacci S. Change in serotonin and catecholamines vascular reactivity during migraine attack. Res Clin Stud Headache. 1970;3:304–309. [PubMed] [Google Scholar]
  7. Gant N. F., Daley G. L., Chand S., Whalley P. J., MacDonald P. C. A study of angiotensin II pressor response throughout primigravid pregnancy. J Clin Invest. 1973 Nov;52(11):2682–2689. doi: 10.1172/JCI107462. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Garoff L., Seppälä M. Toxemia of pregnancy: assessment of fetal distress by urinary estriol and circulating human placental lactogen and alpha-fetoprotein levels. Am J Obstet Gynecol. 1976 Dec 15;126(8):1027–1033. doi: 10.1016/0002-9378(76)90696-7. [DOI] [PubMed] [Google Scholar]
  9. Hanington E., Jones R. J., Amess J. A., Wachowicz B. Migraine: a platelet disorder. Lancet. 1981 Oct 3;2(8249):720–723. doi: 10.1016/s0140-6736(81)91049-7. [DOI] [PubMed] [Google Scholar]
  10. Khalil F. K., Bonnet M., Guibaud S., Combet A., Thoulon J. M., Durmont M. Alpha-fetoprotein levels in placenta, maternal, and cord blood in normal and pathologic pregnancy. Obstet Gynecol. 1979 Jul;54(1):117–119. doi: 10.1097/00006250-197907000-00026. [DOI] [PubMed] [Google Scholar]
  11. LOWE C. R. Toxaemia and pre-pregnancy weight. J Obstet Gynaecol Br Commonw. 1961 Aug;68:622–627. doi: 10.1111/j.1471-0528.1961.tb02780.x. [DOI] [PubMed] [Google Scholar]
  12. Long P. A., Abell D. A., Beischer N. A. Fetal growth retardation and pre-eclampsia. Br J Obstet Gynaecol. 1980 Jan;87(1):13–18. doi: 10.1111/j.1471-0528.1980.tb04419.x. [DOI] [PubMed] [Google Scholar]
  13. MACGILLIVRAY I. Some observations on the incidence of pre-eclampsia. J Obstet Gynaecol Br Emp. 1958 Aug;65(4):536–539. doi: 10.1111/j.1471-0528.1958.tb08557.x. [DOI] [PubMed] [Google Scholar]
  14. Miller D., Waters D. D., Warnica W., Szlachcic J., Kreeft J., Théroux P. Is variant angina the coronary manifestation of a generalized vasospastic disorder? N Engl J Med. 1981 Mar 26;304(13):763–766. doi: 10.1056/NEJM198103263041306. [DOI] [PubMed] [Google Scholar]
  15. ROTTON W. N., SACHTLEBEN M. R., FRIEDMAN E. A. Migraine and eclampsia. Obstet Gynecol. 1959 Sep;14:322–330. [PubMed] [Google Scholar]
  16. Redman C. W., Bonnar J., Beilin L. Early platelet consumption in pre-eclampsia. Br Med J. 1978 Feb 25;1(6111):467–469. doi: 10.1136/bmj.1.6111.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Rodeck C. H., Campbell S., Biswas S. Maternal plasma alpha-fetoprotein in normal and complicated pregnancies. Br J Obstet Gynaecol. 1976 Jan;83(1):24–32. doi: 10.1111/j.1471-0528.1976.tb00725.x. [DOI] [PubMed] [Google Scholar]
  18. Wainscott G., Sullivan F. M., Volans G. N., Wilkinson M. The outcome of pregnancy in women suffering from migraine. Postgrad Med J. 1978 Feb;54(628):98–102. doi: 10.1136/pgmj.54.628.98. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Wald N. J., Cuckle H. S., Boreham J., Turnbull A. C. Maternal serum alpha-fetoprotein and birth weight. Br J Obstet Gynaecol. 1980 Oct;87(10):860–863. doi: 10.1111/j.1471-0528.1980.tb04437.x. [DOI] [PubMed] [Google Scholar]
  20. Waters W. E. Headache and blood pressure in the community. Br Med J. 1971 Jan 16;1(5741):142–143. doi: 10.1136/bmj.1.5741.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Waters W. E., O'Connor P. J. Epidemiology of headache and migraine in women. J Neurol Neurosurg Psychiatry. 1971 Apr;34(2):148–153. doi: 10.1136/jnnp.34.2.148. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Medical Journal (Clinical research ed.) are provided here courtesy of BMJ Publishing Group

RESOURCES