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. 1983 Nov 19;287(6404):1495–1498. doi: 10.1136/bmj.287.6404.1495

Effect of ethanol on vascular prostacyclin (prostaglandin I2) synthesis, platelet aggregation, and platelet thromboxane release.

D P Mikhailidis, J Y Jeremy, M A Barradas, N Green, P Dandona
PMCID: PMC1549984  PMID: 6416473

Abstract

A series of experiments with platelets from healthy volunteers showed a concentration related inhibitory effect of ethanol on platelet aggregation and release of thromboxane A2. This effect was observed at blood alcohol concentrations ranging between 66 and 132 mg/dl (14.3 and 28.6 mmol/l), which are commonly found in alcoholics. Investigations carried out by incubating ethanol with platelet rich plasma in vitro also showed an inverse linear correlation between ethanol concentration and platelet thromboxane synthesis. In contrast, the incubation of a wide range of concentrations of ethanol with human endothelial cells and rat aortic rings did not alter the ability of these systems to synthesise prostacyclin (prostaglandin I2). This finding of a selective inhibition of thromboxane A2 synthesis and platelet aggregation without an alteration of prostaglandin I2 synthesis may provide an explanation for the reported ethanol mediated protection against vascular disease. This effect of ethanol may also be relevant to the induction of acute gastrointestinal haemorrhage that occurs after bouts of excessive alcohol consumption.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Best L. C., Holland T. K., Jones P. B., Russell R. G. The interrelationship between thromboxane biosynthesis, aggregation and 5-hydroxytryptamine secretion in human platelets in vitro. Thromb Haemost. 1980 Feb 29;43(1):38–40. [PubMed] [Google Scholar]
  2. Cowan D. H. Effect of alcoholism on hemostasis. Semin Hematol. 1980 Apr;17(2):137–147. [PubMed] [Google Scholar]
  3. Deykin D., Janson P., McMahon L. Ethanol potentiation of aspirin-induced prolongation of the bleeding time. N Engl J Med. 1982 Apr 8;306(14):852–854. doi: 10.1056/NEJM198204083061406. [DOI] [PubMed] [Google Scholar]
  4. Doll R. Prospects for prevention. Br Med J (Clin Res Ed) 1983 Feb 5;286(6363):445–453. doi: 10.1136/bmj.286.6363.445. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gruchow H. W., Hoffmann R. G., Anderson A. J., Barboriak J. J. Effects of drinking patterns on the relationship between alcohol an coronary occlusion. Atherosclerosis. 1982 Jun;43(2-3):393–404. doi: 10.1016/0021-9150(82)90038-7. [DOI] [PubMed] [Google Scholar]
  6. Hamlyn A. N., Brown A. J., Sherlock S., Baron D. N. Casual blood-ethanol estimations in patients with chronic liver disease. Lancet. 1975 Aug 23;2(7930):345–347. doi: 10.1016/s0140-6736(75)92781-6. [DOI] [PubMed] [Google Scholar]
  7. Hammond K. B., Rumack B. H., Rodgerson D. O. Blood ethanol. A report of unusually high levels in a living patient. JAMA. 1973 Oct 1;226(1):63–64. doi: 10.1001/jama.226.1.63. [DOI] [PubMed] [Google Scholar]
  8. Hirsh P. D., Firth B. G., Campbell W. B., Willerson J. T., Hillis L. D. Influence of blood sampling site and technique on thromboxane concentrations in patients with ischemic heart disease. Am Heart J. 1982 Aug;104(2 Pt 1):234–237. doi: 10.1016/0002-8703(82)90198-3. [DOI] [PubMed] [Google Scholar]
  9. Hudson J., McCaughey W. T. Mural thrombosis and atherogenesis in coronary arteries and aorta. An investigation using antifibrin and antiplatelet sera. Atherosclerosis. 1974 May-Jun;19(3):543–553. doi: 10.1016/s0021-9150(74)80018-3. [DOI] [PubMed] [Google Scholar]
  10. Jeremy J. Y., Mikhailidis D. P., Dandona P. Simulating the diabetic environment modifies in vitro prostacyclin synthesis. Diabetes. 1983 Mar;32(3):217–221. doi: 10.2337/diab.32.3.217. [DOI] [PubMed] [Google Scholar]
  11. Johnson R. A., Noll E. C., Rodney W. M. Survival after a serum ethanol concentration of 1 1/2%. Lancet. 1982 Dec 18;2(8312):1394–1394. doi: 10.1016/s0140-6736(82)91285-5. [DOI] [PubMed] [Google Scholar]
  12. Klatsky A. L., Friedman G. D., Siegelaub A. B. Alcohol and mortality. A ten-year Kaiser-Permanente experience. Ann Intern Med. 1981 Aug;95(2):139–145. doi: 10.7326/0003-4819-95-2-139. [DOI] [PubMed] [Google Scholar]
  13. Kontula K., Viinikka L., Ylikorkala O., Ylikahri R. Effect of acute ethanol intake on thromboxane and prostacyclin in human. Life Sci. 1982 Jul 19;31(3):261–264. doi: 10.1016/0024-3205(82)90587-2. [DOI] [PubMed] [Google Scholar]
  14. Kozararevic D., McGee D., Vojvodic N., Racic Z., Dawber T., Gordon T., Zukel W. Frequency of alcohol consumption and morbidity and mortality: The Yugoslavia Cardiovascular Disease Study. Lancet. 1980 Mar 22;1(8169):613–616. doi: 10.1016/s0140-6736(80)91116-2. [DOI] [PubMed] [Google Scholar]
  15. Marmot M. G., Rose G., Shipley M. J., Thomas B. J. Alcohol and mortality: a U-shaped curve. Lancet. 1981 Mar 14;1(8220 Pt 1):580–583. doi: 10.1016/s0140-6736(81)92032-8. [DOI] [PubMed] [Google Scholar]
  16. Moncada S., Vane J. R. Prostacyclin: homeostatic regulator or biological curiosity? Clin Sci (Lond) 1981 Oct;61(4):369–372. doi: 10.1042/cs0610369. [DOI] [PubMed] [Google Scholar]
  20. Pennington S. N., Smith C. P., Jr The effect of ethanol on thromboxane synthesis by blood platelets. Prostaglandins Med. 1979 Jan;2(1):43–50. doi: 10.1016/s0161-4630(79)80007-5. [DOI] [PubMed] [Google Scholar]
  21. Thorngren M., Shafi S., Born G. V. Thromboxane A2 in skin-bleeding-time blood and in clotted venous blood before and after administration of acetylsalicylic acid. Lancet. 1983 May 14;1(8333):1075–1078. doi: 10.1016/s0140-6736(83)91911-6. [DOI] [PubMed] [Google Scholar]
  22. Yano K., Rhoads G. G., Kagan A., Tillotson J. Dietary intake and the risk of coronary heart disease in Japanese men living in Hawaii. Am J Clin Nutr. 1978 Jul;31(7):1270–1279. doi: 10.1093/ajcn/31.7.1270. [DOI] [PubMed] [Google Scholar]

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