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British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1983 Dec 17;287(6408):1838–1840. doi: 10.1136/bmj.287.6408.1838

Protein composition of urinary casts from healthy subjects and patients with glomerulonephritis.

J K Fairley, J E Owen, D F Birch
PMCID: PMC1550059  PMID: 6423037

Abstract

Urinary casts from 46 healthy volunteers and 60 patients with glomerulonephritis were examined for the presence of Tamm-Horsfall glycoprotein and other proteins. All samples gave immunofluorescence evidence of Tamm-Horsfall protein in casts. Casts from 59 of the patients but only three of the controls contained other proteins in addition (p less than 0.001). Immunoglobulins (IgG, IgM, IgA) were detected in casts from 53 of the patients but none of the healthy volunteers. Examination of urinary casts for immunoglobulins, complement, and fibrin provides a non-invasive method for distinguishing patients with active glomerular disease.

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Selected References

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  1. Birch D. F., Fairley K. F. Haematuria: glomerular or non-glomerular? Lancet. 1979 Oct 20;2(8147):845–846. doi: 10.1016/s0140-6736(79)92191-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Birch D. F., Fairley K. F., Whitworth J. A., Forbes I., Fairley J. K., Cheshire G. R., Ryan G. B. Urinary erythrocyte morphology in the diagnosis of glomerular hematuria. Clin Nephrol. 1983 Aug;20(2):78–84. [PubMed] [Google Scholar]
  3. FRIEDMAN I. S., ZUCKERMAN S., COHN T. D. The production of urinary casts during the use of cation exchange resins. Am J Med Sci. 1951 Jun;221(6):672–677. [PubMed] [Google Scholar]
  4. Fairley K. F., Birch D. F. Hematuria: a simple method for identifying glomerular bleeding. Kidney Int. 1982 Jan;21(1):105–108. doi: 10.1038/ki.1982.16. [DOI] [PubMed] [Google Scholar]
  5. Fassett R. G., Owen J. E., Fairley J., Birch D. F., Fairley K. F. Urinary red-cell morphology during exercise. Br Med J (Clin Res Ed) 1982 Nov 20;285(6353):1455–1457. doi: 10.1136/bmj.285.6353.1455. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Imhof P. R., Hushak J., Schumann G., Dukor P., Wagner J., Keller H. M. Excretion of urinary casts after the administration of diuretics. Br Med J. 1972 Apr 22;2(5807):199–202. doi: 10.1136/bmj.2.5807.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kapoor A., Mowbray J. F., Porter K. A., Peart W. S. Significance of haematuria in hypertensive patients. Lancet. 1980 Feb 2;1(8162):231–232. doi: 10.1016/s0140-6736(80)90718-7. [DOI] [PubMed] [Google Scholar]
  8. McQueen E. G. Composition of urinary casts. Lancet. 1966 Feb 19;1(7434):397–398. doi: 10.1016/s0140-6736(66)91392-4. [DOI] [PubMed] [Google Scholar]
  9. Rutecki G. J., Goldsmith C., Schreiner G. E. Characterization of proteins in urinary casts. Fluorescent-antibody identification of Tamm-Horsfall mucoprotein in matrix and serum proteins in granules. N Engl J Med. 1971 May 13;284(19):1049–1052. doi: 10.1056/NEJM197105132841901. [DOI] [PubMed] [Google Scholar]

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