Skip to main content
NCBI home page
Gut logoLink to Gut
. 1969 Aug;10(8):662–664. doi: 10.1136/gut.10.8.662

Vitamin B12 excretion by the rat small intestine

C A Loehry, B Creamer
PMCID: PMC1552898  PMID: 5810979

Abstract

Two phases of intestinal excretion are demonstrated after a parenteral dose of 58Co vitamin B12. The first phase was maximal immediately after injection, and was related to plasma radioactivity. The second phase was delayed 36 to 48 hours and was related to labelled cells reaching the tips of the villi. The loss of vitamin B12 through increased exudation and rapid cell exfoliation together with failure of reabsorption may play a part in the deficiency state seen in the coeliac syndrome.

Full text

PDF
662

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADAMS J. F. The biliary and faecal loss after parenteral 58Co vitamin B12 in man. Scott Med J. 1963 Mar;8:118–121. doi: 10.1177/003693306300800305. [DOI] [PubMed] [Google Scholar]
  2. BOOTH M. A., SPRAY G. H. The excretion and distribution in the tissues of parenterally administered 58Co-vitamin B12 in normal and gastrectomized rats. Br J Haematol. 1962 Apr;8:114–119. doi: 10.1111/j.1365-2141.1962.tb06503.x. [DOI] [PubMed] [Google Scholar]
  3. CROFT D. N., LUBRAN M. THE ESTIMATION OF DEOXYRIBONUCLEIC ACID IN THE PRESENCE OF SIALIC ACID: APPLICATION TO ANALYSIS OF HUMAN GASTRIC WASHINGS. Biochem J. 1965 Jun;95:612–620. doi: 10.1042/bj0950612. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. GRASBECK R., NYBERG W., REIZENSTEIN P. Biliary and fecal vit. B12 excretion in man: an isotope study. Proc Soc Exp Biol Med. 1958 Apr;97(4):780–784. doi: 10.3181/00379727-97-23879. [DOI] [PubMed] [Google Scholar]
  5. GRASBECK R., RUNEBERG L., SIMONS K. Intrinsic factor and radiovitamin B12 excretion in rats. Acta Physiol Scand. 1959 Dec 12;47:370–374. [PubMed] [Google Scholar]
  6. Loehry C. A., Croft D. N., Singh A. K., Creamer B. Cell turnover in the rat small intestinal mucosa: an appraisal of cell loss. II. Cell loss in rats with an abnormal mucosa. Gut. 1969 Jan;10(1):16–18. doi: 10.1136/gut.10.1.16. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MOLLIN D. L., PITNEY W. R., BAKER S. J., BRADLEY J. E. The plasma clearance and urinary excretion of parenterally administered 58Co B12. Blood. 1956 Jan;11(1):31–43. [PubMed] [Google Scholar]
  8. OKUDA K., GRASBECK R., CHOW B. F. Bile and vitamin B12 absorption. J Lab Clin Med. 1958 Jan;51(1):17–23. [PubMed] [Google Scholar]
  9. WILLIGAN D. A., CRONKITE E. P., MEYER L. M., NOTO S. L. Biliary excretion of Co60 labeled vitamin B12 in dogs. Proc Soc Exp Biol Med. 1958 Oct;99(1):81–84. doi: 10.3181/00379727-99-24254. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES