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. 1969 Sep;10(9):705–710. doi: 10.1136/gut.10.9.705

Postmortem study of the frequency of gallstones in patients with cirrhosis of the liver

Ian A D Bouchier
PMCID: PMC1552971  PMID: 5386627

Abstract

The frequency of gallstones in cirrhotic and non-cirrhotic patients at necropsy has been determined from a retrospective survey of postmortem records over 15 years. The frequency of gallstones was found to be 29·4% in the cirrhotic group and 12·8% in the non-cirrhotic population. Whereas gallstones were twice as frequent in females than males in the general population the sex difference disappeared in cirrhotic patients. Gallstones increased in frequency with age in the general population but this phenomenon was not seen in the cirrhotic group. No one type of cirrhosis was more liable to be associated with gallstones at necropsy. In contrast to the general population bilirubin stones were more frequent in cirrhotics.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bergman F., van der Linden W., Söderström J. The connexion between myocardial infarction and gallstones in an autopsy series. Acta Pathol Microbiol Scand. 1968;73(4):559–564. doi: 10.1111/j.1699-0463.1968.tb03213.x. [DOI] [PubMed] [Google Scholar]
  2. Bouchier I. A., Freston J. W. The aetiology of gallstones. Lancet. 1968 Feb 17;1(7538):340–344. doi: 10.1016/s0140-6736(68)90801-5. [DOI] [PubMed] [Google Scholar]
  3. CAWEIN M. J., 3rd, HAGEDORN A. B., OWEN C. A., Jr Anemia of hepatic disease studied with radiochromium. Gastroenterology. 1960 Mar;38:324–331. [PubMed] [Google Scholar]
  4. DAVIDSON J. F. Alcohol and cholelithiasis: a necropsy survey of cirrhotics. Am J Med Sci. 1962 Dec;244:703–705. doi: 10.1097/00000441-196212000-00005. [DOI] [PubMed] [Google Scholar]
  5. EDHOLM P., JONSSON G. Bile duct stones related to age and duct width. Acta Chir Scand. 1962 Jul;124:75–79. [PubMed] [Google Scholar]
  6. Friedman G. D., Kannel W. B., Dawber T. R. The epidemiology of gallbladder disease: observations in the Framingham Study. J Chronic Dis. 1966 Mar;19(3):273–292. doi: 10.1016/0021-9681(66)90132-9. [DOI] [PubMed] [Google Scholar]
  7. GLENN F., BEIL A. R., Jr CHOLEDOCHOLITHIASIS DEMONSTRATED AT 586 OPERATIONS. Surg Gynecol Obstet. 1964 Mar;118:499–506. [PubMed] [Google Scholar]
  8. HORN G. Observations on the aetiology of cholelithiasis. Br Med J. 1956 Sep 29;2(4995):732–737. doi: 10.1136/bmj.2.4995.732. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. JANDL J. H. The anemia of liver disease: observations on its mechanism. J Clin Invest. 1955 Mar;34(3):390–404. doi: 10.1172/JCI103087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. JONES P. N., WEINSTEIN I. M., ETTINGER R. H., CAPPS R. B. Decreased red cell survival associated with liver disease; use of radioactive sodium chromate in measurement of red cell survival. AMA Arch Intern Med. 1955 Jan;95(1):93–102. doi: 10.1001/archinte.1955.00250070109013. [DOI] [PubMed] [Google Scholar]
  11. JUNIPER K., Jr The relationship of a biliary lipoprotein complex to some theories of gallstone formation. Am Surg. 1958 Jan;24(1):45–56. [PubMed] [Google Scholar]
  12. LIEBER M. M. The incidence of gallstones and their correlation with other diseases. Ann Surg. 1952 Mar;135(3):394–405. doi: 10.1097/00000658-195203000-00011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. MAINLAND D. The risk of fallacious conclusions from autopsy data on the incidence of diseases with applications to heart disease. Am Heart J. 1953 May;45(5):644–654. doi: 10.1016/0002-8703(53)90306-8. [DOI] [PubMed] [Google Scholar]
  14. Madden J. L., Vanderheyden L., Kandalaft S. The nature and surgical significance of common duct stones. Surg Gynecol Obstet. 1968 Jan;126(1):3–8. [PubMed] [Google Scholar]
  15. OSBORN E. C., WOOTTON I. D., da SILVA L., SHERLOCK S. Serum-bile-acid levels in liver disease. Lancet. 1959 Dec 12;2(7111):1049–1053. doi: 10.1016/s0140-6736(59)91527-2. [DOI] [PubMed] [Google Scholar]
  16. TORVIK A., HOIVIK B. Gallstones in an autopsy series. Incidence, complications, and correlations with carcinoma of the gallbladder. Acta Chir Scand. 1960 Nov 25;120:168–174. [PubMed] [Google Scholar]
  17. Tamesue N., Juniper K., Jr Concentrations of bile salts at the critical micellar concentration of human gall bladder bile. Gastroenterology. 1967 Mar;52(3):473–479. [PubMed] [Google Scholar]
  18. WANTZ G. E., PAYNE M. A. Experience with portacaval shunt for portal hypertension. N Engl J Med. 1961 Oct 12;265:721–728. doi: 10.1056/NEJM196110122651502. [DOI] [PubMed] [Google Scholar]
  19. WEBSTER D. R., CAIRA E. G. Changing concepts of gallstone formation. Am Surg. 1959 Jan;25(1):12–17. [PubMed] [Google Scholar]

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