Skip to main content
PMC home page
Gut logoLink to Gut
. 1969 Sep;10(9):730–734. doi: 10.1136/gut.10.9.730

Action of gastrin on the lower oesophageal sphincter in man

G R Giles, M C Mason, C Humphries, C G Clark
PMCID: PMC1552975  PMID: 5386630

Abstract

Both hog gastrin and synthetic gastrin stimulate the cardiac sphincter to increase tone and augment the resistance to reflux. Endogenous gastrin has a similar effect, and gastrin also stimulates the secretion of acid which has also been found to increase the resistance of the sphincter, but the effect of gastrin appears to be independent of the secretory stimulus.

Full text

PDF
730

Images in this article

731FIG. 1
on p.731
733FIG. 8
on p.733

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BINGHAM J. A. Oesophageal strictures after gastric surgery and naso-gastric intubation. Br Med J. 1958 Oct 4;2(5100):817–819. doi: 10.1136/bmj.2.5100.817. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bennett A. Effect of gastrin on isolated smooth muscle preparation. Nature. 1965 Oct 9;208(5006):170–173. doi: 10.1038/208170a0. [DOI] [PubMed] [Google Scholar]
  3. Bennett A., Misiewicz J. J., Waller S. L. Analysis of the motor effects of gastrin and pentagastrin on the human alimentary tract in vitro. Gut. 1967 Oct;8(5):470–474. doi: 10.1136/gut.8.5.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. COX K. R. Oesophageal stricture after partial gastrectomy. Br J Surg. 1961 Nov;49:307–313. doi: 10.1002/bjs.18004921515. [DOI] [PubMed] [Google Scholar]
  5. GREGORY R. A., TRACY H. J. THE CONSTITUTION AND PROPERTIES OF TWO GASTRINS EXTRACTED FROM HOG ANTRAL MUCOSA. Gut. 1964 Apr;5:103–114. [PMC free article] [PubMed] [Google Scholar]
  6. Giles G. R., Clark C. G., Buchan R. Effect of oesophageal perfusion with acid on basal gastric secretion. Gut. 1968 Feb;9(1):52–56. doi: 10.1136/gut.9.1.52. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Giles G. R., Clark C. G. Gastric secretion stimulated by meat extract in man. Scand J Gastroenterol. 1966;1(3):159–166. doi: 10.1080/00365521.1966.11800629. [DOI] [PubMed] [Google Scholar]
  8. Logan C. J., Connell A. M. The effect of a synthetic gastrin-like pentapeptide (I.C.I. 50,123) on intestinal motility in man. Lancet. 1966 May 7;1(7445):996–999. doi: 10.1016/s0140-6736(66)90111-5. [DOI] [PubMed] [Google Scholar]
  9. Mikos E., Vane J. R. Effects of gastrin and its analogues on isolated smooth muscles. Nature. 1967 Apr 1;214(5083):105–107. doi: 10.1038/214105a0. [DOI] [PubMed] [Google Scholar]
  10. Misiewicz J. J., Holdstock D. J., Waller S. L. Motor responses of the human alimentary tract to near-maximal infusions of pentagastrin. Gut. 1967 Oct;8(5):463–469. doi: 10.1136/gut.8.5.463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Neely J. Comparison of the effects of a gastrin extract and a synthetic pentapeptide on gastrointestinal motility in the cat. Gut. 1967 Jun;8(3):242–248. doi: 10.1136/gut.8.3.242. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Smith A. N., Hogg D. Effect of gastrin II on the motility of the gastrointestinal tract. Lancet. 1966 Feb 19;1(7434):403–404. doi: 10.1016/s0140-6736(66)91396-1. [DOI] [PubMed] [Google Scholar]
  13. WINDSOR C. W. GASTRO-OESOPHAGEAL REFLUX AFTER PARTIAL GASTRECTOMY. Br Med J. 1964 Nov 14;2(5419):1233–1234. doi: 10.1136/bmj.2.5419.1233. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES