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. 1969 Sep;10(9):723–729. doi: 10.1136/gut.10.9.723

Gastrointestinal motility and gastric secretion during intravenous infusions of gastrin II

J J Misiewicz, Sheila L Waller, D J Holdstock
PMCID: PMC1552979  PMID: 5386629

Abstract

The effect of intravenous infusion of gastrin II on gastric and colonic motor activity was studied in 12 patients; gastric acid output was also measured. Administration of gastrin at near-maximal dose levels stimulates the motor activity of the antrum but has no measurable effect on the activity of the proximal colon, sigmoid, or rectum. The results suggest that gastrin plays a part in the regulation of gastric motility but that it is not a mediator of the gastro-colic reflex.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett A., Misiewicz J. J., Waller S. L. Analysis of the motor effects of gastrin and pentagastrin on the human alimentary tract in vitro. Gut. 1967 Oct;8(5):470–474. doi: 10.1136/gut.8.5.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bertaccini G., De Caro G., Endean R., Erspamer V., Impicciatore M. The actions of caerulein on the smooth muscle of the gastrointestinal tract and the gall bladder. Br J Pharmacol. 1968 Oct;34(2):291–310. doi: 10.1111/j.1476-5381.1968.tb07052.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. George J. D. New clinical method for measuring the rate of gastric emptying: the double sampling test meal. Gut. 1968 Apr;9(2):237–242. doi: 10.1136/gut.9.2.237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Griffith G. H., Owen G. M., Campbell H., Shields R. Gastric emptying in health and in gastroduodenal disease. Gastroenterology. 1968 Jan;54(1):1–7. [PubMed] [Google Scholar]
  5. Grossman M. I. Physiological role of gastrin. Fed Proc. 1968 Nov-Dec;27(6):1312–1313. [PubMed] [Google Scholar]
  6. Hunt J. N., Ramsbottom N. Effect of gastrin II on gastric emptying and secretion during a test meal. Br Med J. 1967 Nov 18;4(5576):386–387. doi: 10.1136/bmj.4.5576.386. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Logan C. J., Connell A. M. The effect of a synthetic gastrin-like pentapeptide (I.C.I. 50,123) on intestinal motility in man. Lancet. 1966 May 7;1(7445):996–999. doi: 10.1016/s0140-6736(66)90111-5. [DOI] [PubMed] [Google Scholar]
  8. MAKHLOUF G. M., MCMANUS J. P., CARD W. I. DOSE-RESPONSE CURVES FOR THE EFFECT OF GASTRIN II ON ACID GASTRIC SECRETION IN MAN. Gut. 1964 Oct;5:379–384. doi: 10.1136/gut.5.5.379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mack A. J., Todd J. K. A study of human gall bladder muscle in vitro. Gut. 1968 Oct;9(5):546–549. doi: 10.1136/gut.9.5.546. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Misiewicz J. J., Holdstock D. J., Waller S. L. Motor responses of the human alimentary tract to near-maximal infusions of pentagastrin. Gut. 1967 Oct;8(5):463–469. doi: 10.1136/gut.8.5.463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Misiewicz J. J., Waller S. L., Fox R. H., Goldsmith R., Hunt T. J. The effect of elevated body temperature and of stress on the motility of stomach and colon in man. Clin Sci. 1968 Feb;34(1):149–159. [PubMed] [Google Scholar]
  12. Misiewicz J. J., Waller S. L., Healy M. J., Piper E. A. Computer analysis of intraluminal pressure records. Gut. 1968 Apr;9(2):232–236. doi: 10.1136/gut.9.2.232. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Morley J. S. Structure--function relationships in gastrin-like peptides. Proc R Soc Lond B Biol Sci. 1968 May 14;170(1018):97–111. doi: 10.1098/rspb.1968.0028. [DOI] [PubMed] [Google Scholar]
  14. Rune S. J. Comparison of the rates of gastric acid secretion in man after ingestion of food and after maximal stimulation with histamine. Gut. 1966 Aug;7(4):344–350. doi: 10.1136/gut.7.4.344. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Smith A. N., Hogg D. Effect of gastrin II on the motility of the gastrointestinal tract. Lancet. 1966 Feb 19;1(7434):403–404. doi: 10.1016/s0140-6736(66)91396-1. [DOI] [PubMed] [Google Scholar]
  16. TRACY H. J., GREGORY R. A. PHYSIOLOGICAL PROPERTIES OF A SERIES OF SYNTHETIC PEPTIDES STRUCTURALLY RELATED TO GASTRIN I. Nature. 1964 Dec 5;204:935–938. doi: 10.1038/204935a0. [DOI] [PubMed] [Google Scholar]
  17. Vagne M., Grossman M. I. Cholecystokinetic potency of gastrointestinal hormones and related peptides. Am J Physiol. 1968 Oct;215(4):881–884. doi: 10.1152/ajplegacy.1968.215.4.881. [DOI] [PubMed] [Google Scholar]

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