Skip to main content
Gut logoLink to Gut
. 1969 Oct;10(10):800–803. doi: 10.1136/gut.10.10.800

The Zollinger-Ellison syndrome in a child

H B C Burmester, R Hall, N Munawer
PMCID: PMC1552989  PMID: 4310768

Abstract

The Zollinger-Ellison syndrome was encountered in a boy aged 11 years who presented with a bulbar duodenal ulcer causing intractable pain and bleeding. The diagnosis was made by finding an overnight fasting gastric secretion of 1,300 ml containing 134 m-equiv/HCl, and little change of secretion after maximal histamine stimulus. A circumscribed non-beta islet cell pancreatic tumour was excised, with antrectomy. Postoperative acid secretion was normal and the boy was well after being followed up for 15 months. The diagnosis and management are discussed, as the view that total gastrectomy must be performed in all cases of the Zollinger-Ellison syndrome is questioned.

Full text

PDF
800

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AMBERG J. R., ELLISON E. H., WILSON S. D., ZBORALSKE F. F. ROENTGENOGRAPHIC OBSERVATIONS IN THE ZOLLINGER-ELLISON SYNDROME. JAMA. 1964 Oct 19;190:185–187. doi: 10.1001/jama.1964.03070160009002. [DOI] [PubMed] [Google Scholar]
  2. FORTY F., BARRETT G. M. Peptic ulceration of the third part of the duodenum, associated with islet-cell Tumors of the pancreas. Br J Surg. 1952 Jul;40(159):60–63. doi: 10.1002/bjs.18004015912. [DOI] [PubMed] [Google Scholar]
  3. GOLDBERG H. M. Duodenal ulcers in children. Br Med J. 1957 Jun 29;1(5034):1500–1502. doi: 10.1136/bmj.1.5034.1500. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. GREGORY R. A., TRACY H. J., FRENCH J. M., SIRCUS W. Extraction of a gastrin-like substance from a pancreatic tumour in a case of Zollinger-Ellison syndrome. Lancet. 1960 May 14;1(7133):1045–1048. doi: 10.1016/s0140-6736(60)90932-6. [DOI] [PubMed] [Google Scholar]
  5. GREGORY R. A., TRACY H. J. THE CONSTITUTION AND PROPERTIES OF TWO GASTRINS EXTRACTED FROM HOG ANTRAL MUCOSA. Gut. 1964 Apr;5:103–114. [PMC free article] [PubMed] [Google Scholar]
  6. Gregory R. A., Grossman M. I., Tracy H. J., Bentley P. H. Nature of the gastric secretagogue in Zollinger-Ellison tumours. Lancet. 1967 Sep 9;2(7515):543–544. doi: 10.1016/s0140-6736(67)90501-6. [DOI] [PubMed] [Google Scholar]
  7. JACKSON R. H., BLAIR E. L., DAWSON P. J., REED J. D., WATTS W. P. GASTRIN ACTIVITY OF TUMOUR TISSUEIN A CHILD WITH THE ZOLLINGER-ELLISON SYNDROME. Lancet. 1963 Nov 2;2(7314):908–912. doi: 10.1016/s0140-6736(63)90619-6. [DOI] [PubMed] [Google Scholar]
  8. MICHENER W. M., KENNEDY R. L., DUSHANE J. W. Duodenal ulcer in childhood. Ninety-two cases with follow-up. Am J Dis Child. 1960 Dec;100:814–817. doi: 10.1001/archpedi.1960.04020040816003. [DOI] [PubMed] [Google Scholar]
  9. RAMIREZ RAMOS A., KIRSNER J. B., PALMER W. L. Pepticulcer in children. Review of literature and report of thirty-two cases. AMA J Dis Child. 1960 Feb;99:135–148. [PubMed] [Google Scholar]
  10. WEBER J. M., LEWIS S., HEASLEY K. H. Observations on the small bowel pattern associated with the Zollinger-Ellison syndrome. Am J Roentgenol Radium Ther Nucl Med. 1959 Dec;82:973–977. [PubMed] [Google Scholar]
  11. ZOLLINGER R. M., ELLISON E. H. Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg. 1955 Oct;142(4):709-23; discussion, 724-8. [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES