Abstract
A systematic study of the distribution of Paneth cells in disease of the small and large intestine is described. In disease of the small intestine and appendix there is usually a fall in the number of Paneth cells normally present. Occasionally, as in Crohn's disease, there may be proliferation. In disease of the colon the number of Paneth cells is unaltered in functional and developmental disorders and increased in the inflammatory and neoplastic diseases. It is suggested that the Paneth cell proliferation originates from stem cells in the colon.
The significance of an increase in Paneth cells is discussed and it is suggested that in ulcerative colitis it may produce a self-perpetuating and destructive state.
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- Creamer B., Pink I. J. Paneth-cell deficiency. Lancet. 1967 Feb 11;1(7485):304–306. doi: 10.1016/s0140-6736(67)91239-1. [DOI] [PubMed] [Google Scholar]
- Gibbs N. M. Incidence and significance of argentaffin and paneth cells in some tumours of the large intestine. J Clin Pathol. 1967 Nov;20(6):826–831. doi: 10.1136/jcp.20.6.826. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hertzog A. J. The Paneth Cell. Am J Pathol. 1937 May;13(3):351–360.1. [PMC free article] [PubMed] [Google Scholar]
- Lewin K. The Paneth cell in health and disease. Ann R Coll Surg Engl. 1969 Jan;44(1):23–37. [PMC free article] [PubMed] [Google Scholar]
- MORSON B. C. Gastric polyps composed of intestinal epithelium. Br J Cancer. 1955 Dec;9(4):550–557. doi: 10.1038/bjc.1955.56. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PATERSON J. C., WATSON S. H. Paneth cell metaplasia in ulcerative colitis. Am J Pathol. 1961 Feb;38:243–249. [PMC free article] [PubMed] [Google Scholar]
- VERITY M. A., MELLINKOFF S. M., FRANKLAND M., GREIPEL M. Serotonin content and argentaffin and Paneth cell changes in ulcerative colitis. Gastroenterology. 1962 Jul;43:24–31. [PubMed] [Google Scholar]