Skip to main content
Gut logoLink to Gut
. 1969 Oct;10(10):796–799. doi: 10.1136/gut.10.10.796

Secretory response to secretin in a patient with diarrhoea and the Zollinger-Ellison pattern of gastric secretion

H Petersen, J Myren, I Liavåg
PMCID: PMC1553005  PMID: 5350104

Abstract

In a woman with diarrhoea and the Zollinger-Ellison pattern of gastric secretion, the secretion of fluid and bicarbonate into the duodenum in response to secretin was found to be significantly greater than in controls. No pancreatic tumour was found at operation. The pancreas was, however, larger than normal.

The patient did not show symptoms of peptic ulcer disease until vagotomy and pyloroplasty had been performed. A capacity to secrete large amounts of bicarbonate was believed to be the explanation of why she was able to tolerate great amounts of acid.

Full text

PDF
796

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cook H. B., French A. B. Physiologic responses to gastric acid hypersecretion in Zollinger-Ellison syndrome. Am J Dig Dis. 1968 Mar;13(3):191–203. doi: 10.1007/BF02236593. [DOI] [PubMed] [Google Scholar]
  2. DONALDSON R. M., Jr, VOM EIGEN P. R., DWIGHT R. W. Gastric hypersecretion, peptic ulceration and islet-cell tumor of the pancreas (the Zollinger-Ellison syndrome); report of a case and review of the literature. N Engl J Med. 1957 Nov 14;257(20):965–970. doi: 10.1056/NEJM195711142572003. [DOI] [PubMed] [Google Scholar]
  3. Jorpes J. E. The isolation and chemistry of secretin and cholecystokinin. Gastroenterology. 1968 Aug;55(2):157–164. [PubMed] [Google Scholar]
  4. KAY A. W. Effect of large doses of histamine on gastric secretion of HCI; an augmented histamine test. Br Med J. 1953 Jul 11;2(4827):77–80. doi: 10.1136/bmj.2.4827.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Konturek S. J. The effect of secretin on gastric acid secretion and peptic ulcers induced by pentagastrin in cats with intact or resected duodenum. Am J Dig Dis. 1968 Oct;13(10):874–881. doi: 10.1007/BF02237572. [DOI] [PubMed] [Google Scholar]
  6. MAYNARD E. P., 3rd, POINT W. W. Steatorrhea associated with ulcerogenic tumor of the pancreas. Am J Med. 1958 Sep;25(3):456–459. doi: 10.1016/0002-9343(58)90085-8. [DOI] [PubMed] [Google Scholar]
  7. Mann F. C., Williamson C. S. THE EXPERIMENTAL PRODUCTION OF PEPTIC ULCER. Ann Surg. 1923 Apr;77(4):409–422. doi: 10.1097/00000658-192304000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Petersen H. The relationship between the gastric and pancreatic secretion in man. Scand J Gastroenterol. 1969;4(4):345–351. doi: 10.3109/00365526909180615. [DOI] [PubMed] [Google Scholar]
  9. RAWSON A. B., ENGLAND M. T., GILLAM G. G., FRENCH J. M., STAMMERS F. A. Zollinger-Ellison syndrome with diarrhoea and malabsorption. Observations on a patient before and after pancreatic islet-cell tumour removal with-out resort. Lancet. 1960 Jul 16;2(7142):131–134. doi: 10.1016/s0140-6736(60)91271-x. [DOI] [PubMed] [Google Scholar]
  10. SHAY H., CHEY W. Y., KOIDE S. M., BURNETT W. E. Mechanism of the disordered physiology involved in the Zollinger-Ellison syndrome. Report of a case. Am J Dig Dis. 1962 May;7:401–419. doi: 10.1007/BF02232360. [DOI] [PubMed] [Google Scholar]
  11. SUMMERSKILL W. H. Malabsorption and jejunal ulceration due to gastric hypersecretion with pancreatic islet-cell hyperplasia. Lancet. 1959 Jan 17;1(7064):120–123. doi: 10.1016/s0140-6736(59)90003-0. [DOI] [PubMed] [Google Scholar]
  12. Vogel R. M., Weinstein L. D., Herskovic T., Spiro H. M. Mechanisms of steatorrhea in the Zollinger-Ellison syndrome. Ann Intern Med. 1967 Oct;67(4):816–822. doi: 10.7326/0003-4819-67-4-816. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES