Abstract
Examination of human gastric biopsies by an indirect immunofluorescence technique using antihuman gastrin confirms the variability in distribution and number of gastrin-secreting (G) cells (Solcia, Vassallo, and Capella, 1969) observed by morphological, cytochemical, and electron microscopical studies. In cases with presumed secondary hypersecretion a profound degree of G-cell hyperplasia is observed. Immunofluorescence with. antigastrin can provide valuable information on the state of the G cells in different physiological states, particularly if used in conjunction with other cytochemical techniques.
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- Graham R. C., Jr, Karnovsky M. J. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. J Histochem Cytochem. 1966 Apr;14(4):291–302. doi: 10.1177/14.4.291. [DOI] [PubMed] [Google Scholar]
- McGuigan J. E. Gastric mucosal intracellular localization of gastrin by immunofluorescence. Gastroenterology. 1968 Sep;55(3):315–327. [PubMed] [Google Scholar]
- Pearse A. G., Coulling I., Weavers B., Friesen S. The endocrine polypeptide cells of the human stomach, duodenum, and jejunum. Gut. 1970 Aug;11(8):649–658. doi: 10.1136/gut.11.8.649. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Solcia E., Vassallo G., Capella C. Studies on the G cells of the pyloric mucosa, the probable site of gastrin secretion. Gut. 1969 May;10(5):379–388. doi: 10.1136/gut.10.5.379. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wood B. T., Thompson S. H., Goldstein G. Fluorescent antibody staining. 3. Preparation of fluorescein-isothiocyanate-labeled antibodies. J Immunol. 1965 Aug;95(2):225–229. [PubMed] [Google Scholar]