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. 1970 Aug;11(8):635–640. doi: 10.1136/gut.11.8.635

Immunoglobulins and dietary protein antibodies in childhood coeliac disease 1

K G Kenrick, J A Walker-Smith
PMCID: PMC1553094  PMID: 4097173

Abstract

Twenty-four children with coeliac disease were compared with a control group, comprising 17 children with a variety of gastroenterological disorders, with respect to serum immunoglobulins and dietary protein antibodies. Elevated levels of IgA and abnormally low levels of IgM were demonstrated in one third of the coeliac patients. Antibodies to at least one of eight dietary proteins were found in 50% of coeliac children. Three children with raised levels of serum IgA and two with deficient IgM were re-examined after varying periods on a gluten-free diet. Antibodies to dietary proteins had waned and immunoglobulin levels returned to normal in all cases. The raised IgA was considered to have resulted from an extensive immunological response to antigens of dietary origin which had entered through the abnormal gut mucosa. It is suggested that IgM deficiency was due to specific inhibition of IgM synthesis by dietary components which had also entered through the mucosa.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allansmith M., McClellan B. H., Butterworth M., Maloney J. R. The development of immunoglobulin levels in man. J Pediatr. 1968 Feb;72(2):276–290. doi: 10.1016/s0022-3476(68)80324-5. [DOI] [PubMed] [Google Scholar]
  2. Austad W. I., Cornes J. S., Gough K. R., McCarthy C. F., Read A. E. Steatorrhea and malignant lymphoma. The relationship of malignant tumors of lymphoid tissue and celiac disease. Am J Dig Dis. 1967 May;12(5):475–490. doi: 10.1007/BF02233180. [DOI] [PubMed] [Google Scholar]
  3. Blecher T. E., Brzechwa-Ajdukiewicz A., McCarthy C. F., Read A. E. Serum immunoglobulins and lymphocyte transformation studies in coeliac disease. Gut. 1969 Jan;10(1):57–62. doi: 10.1136/gut.10.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown D. L., Cooper A. G., Hepner G. W. IgM metabolism in coeliac disease. Lancet. 1969 Apr 26;1(7600):858–861. doi: 10.1016/s0140-6736(69)91901-1. [DOI] [PubMed] [Google Scholar]
  5. Brunt P. W., Sircus W., Maclean N. Neoplasia and the coeliac syndrome in adults. Lancet. 1969 Jan 25;1(7587):180–184. doi: 10.1016/s0140-6736(69)91192-1. [DOI] [PubMed] [Google Scholar]
  6. CRABBE P. A., CARBONARA A. O., HEREMANS J. F. THE NORMAL HUMAN INTESTINAL MUCOSA AS A MAJOR SOURCE OF PLASMA CELLS CONTAINING GAMMA-A-IMMUNOGLOBULIN. Lab Invest. 1965 Mar;14:235–248. [PubMed] [Google Scholar]
  7. DICKE W. K., WEIJERS H. A., VAN DE KAMER J. H. Coeliac disease. II. The presence in wheat of a factor having a deleterious effect in cases of coeliac disease. Acta Paediatr. 1953 Jan;42(1):34–42. doi: 10.1111/j.1651-2227.1953.tb05563.x. [DOI] [PubMed] [Google Scholar]
  8. Douglas A. P., Booth C. C. Jejunal mucosal digestion of gluten peptides in adult coeliac disease. Lancet. 1968 Aug 31;2(7566):491–492. doi: 10.1016/s0140-6736(68)90651-x. [DOI] [PubMed] [Google Scholar]
  9. Gelfand M. D., Spiro H. M., Herskovic T. Small intestine glutaminase deficiency in celiac disease. Am J Dig Dis. 1968 Jul;13(7):638–642. doi: 10.1007/BF02232971. [DOI] [PubMed] [Google Scholar]
  10. Harris O. D., Cooke W. T., Thompson H., Waterhouse J. A. Malignancy in adult coeliac disease and idiopathic steatorrhoea. Am J Med. 1967 Jun;42(6):899–912. doi: 10.1016/0002-9343(67)90071-x. [DOI] [PubMed] [Google Scholar]
  11. Housley J., Asquith P., Cooke W. T. Immune response to gluten in adult coeliac disease. Br Med J. 1969 Apr 19;2(5650):159–161. doi: 10.1136/bmj.2.5650.159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Immonen P. Levels of the serum immunoglobulins gamma-A, gamma-G and gamma-M in the malabsorption syndrome in children. Ann Paediatr Fenn. 1967;13(4):115–153. [PubMed] [Google Scholar]
  13. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  14. McCarthy C. F., Fraser I. D., Evans K. T., Read A. E. Lymphoreticular dysfunction in idiopathic steatorrhoea. Gut. 1966 Apr;7(2):140–148. doi: 10.1136/gut.7.2.140. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. OUCHTERLONY O. Diffusion-in-gel methods for immunological analysis. II. Prog Allergy. 1962;6:30–154. doi: 10.1159/000313795. [DOI] [PubMed] [Google Scholar]
  16. RUBIN W., FAUCI A. S., MARVIN S. F., SLEISENGER M. H., JEFRIES G. H. IMMUNOFLUORESCENT STUDIES IN ADULT CELIAC DISEASE. J Clin Invest. 1965 Mar;44:475–485. doi: 10.1172/JCI105161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Rubin C. E., Dobbins W. O., 3rd Peroral biopsy of the small intestine. A review of its diagnostic usefulness. Gastroenterology. 1965 Dec;49(6):676–697. [PubMed] [Google Scholar]
  18. Smith R. T. Gamma-A immunoglobulins and the concept of local immunity. Pediatrics. 1969 Mar;43(3):317–321. [PubMed] [Google Scholar]
  19. TAYLOR K. B. ROLE OF IMMUNE RESPONSES IN THE GASTROINTESTINAL TRACT. Fed Proc. 1965 Jan-Feb;24:23–28. [PubMed] [Google Scholar]
  20. TOMASI T. B., Jr, TAN E. M., SOLOMON A., PRENDERGAST R. A. CHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONS. J Exp Med. 1965 Jan 1;121:101–124. doi: 10.1084/jem.121.1.101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Villa M. L., Mocarelli P., Natale N., Clerici E. Inhibition of the macroglobulinaemic phase of the antibody responses. Nature. 1968 Dec 7;220(5171):1051–1052. doi: 10.1038/2201051a0. [DOI] [PubMed] [Google Scholar]

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