Skip to main content
NCBI home page
Gut logoLink to Gut
. 1970 Aug;11(8):641–645. doi: 10.1136/gut.11.8.641

Sex hormones and acid gastric secretion induced with carbachol, histamine, and gastrin

B O Amure, A A Omole
PMCID: PMC1553101  PMID: 5471030

Abstract

This study confirms previous reports that satisfactory gastric acid secretory responses to intravenous administration of histamine, carbachol, and gastrin can be obtained.

Bilateral castration of the male rats significantly reduced acid gastric secretory responses to carbachol but not to histamine.

Overiectomized rats treated with 17B-oestradiol (short-term treatment) showed a statistically significant reduction in gastric acid secretion induced with all the secretagogues, but the results when rats were treated with testosterone were inconsistent. In animals given gastrin or histamine gastric acid secretion was reduced and was of statistical significance with gastrin (0·02 < p < 0·05) but not with histamine (0·05 < p > 0·1).

It is concluded that a high oestrogen blood level is capable of inhibiting effectively acid gastric secretion in both sexes except that a higher level of blood oestrogen is required in the male. The results showed further that of all the sex hormones used, only oestrogen had a significant effect on gastric acid secretion.

Full text

PDF
641

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AMURE B. O., GINSBURG M. INHIBITORS OF HISTAMINE CATABOLISM AND THE ACTION OF GASTRIN IN THE RAT. Br J Pharmacol Chemother. 1964 Dec;23:476–485. doi: 10.1111/j.1476-5381.1964.tb01604.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BARON J. H. Studies of basal and peak acid output with an augmented histamine test. Gut. 1963 Jun;4:136–144. doi: 10.1136/gut.4.2.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CLARK D. H. Gastric acid secretion in dogs during pregnancy and lactation. Scott Med J. 1957 Oct;2(10):392–395. doi: 10.1177/003693305700201003. [DOI] [PubMed] [Google Scholar]
  4. DOLL R., HILL I. D., HUTTON C. F. TREATMENT OF GASTRIC ULCER WITH CARBENOXOLONE SODIUM AND OESTROGENS. Gut. 1965 Feb;6:19–24. doi: 10.1136/gut.6.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. GHOSH M. N. Inhibition of acid gastric secretion in the rat by chorionic gonadotrophin. J Physiol. 1959 Oct;147:585–590. doi: 10.1113/jphysiol.1959.sp006263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GHOSH M. N., SCHILD H. O. Continuous recording of acid gastric secretion in the rat. Br J Pharmacol Chemother. 1958 Mar;13(1):54–61. doi: 10.1111/j.1476-5381.1958.tb00190.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HAGEN A. A., TROOP R. C. Influence of age, sex and adrenocortical status on hepatic reduction of cortisone in vitro. Endocrinology. 1960 Aug;67:194–203. doi: 10.1210/endo-67-2-194. [DOI] [PubMed] [Google Scholar]
  8. HUNT J. N., MURRAY F. A. Gastric function in pregnancy. J Obstet Gynaecol Br Emp. 1958 Feb;65(1):78–83. doi: 10.1111/j.1471-0528.1958.tb06212.x. [DOI] [PubMed] [Google Scholar]
  9. KAHLSON G., ROSENGREN E., SVAHN D., THUNBERG R. MOBILIZATION AND FORMATION OF HISTAMINE IN THE GASTRIC MUCOSA AS RELATED TO ACID SECRETION. J Physiol. 1964 Nov;174:400–416. doi: 10.1113/jphysiol.1964.sp007494. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kaufmann H. J., Spiro H. M. Estrogens and gastric secretion. Gastroenterology. 1968 May;54(5):913–917. [PubMed] [Google Scholar]
  11. LOZZIO B. B., GAGLIARDI O. P., BIEMPICA L., ROYER M. Effects of pregnancy on gastric secretion in rats. Gastroenterology. 1961 Aug;41:126–128. [PubMed] [Google Scholar]
  12. MACDONALD I. Gastric activity during the menstrual cycle. Gastroenterology. 1956 Apr;30(4):602–607. [PubMed] [Google Scholar]
  13. MURRAY F. A., ERSKINE J. P., FIELDING J. Gastric secretion in pregnancy. J Obstet Gynaecol Br Emp. 1957 Jun;64(3):373–381. doi: 10.1111/j.1471-0528.1957.tb02656.x. [DOI] [PubMed] [Google Scholar]
  14. McCARTHY J. D., EVANS S. O., DRAGSTEDT L. R. Gastric secretion in dogs during pregnancy and lactation. Gastroenterology. 1954 Sep;27(3):275–280. [PubMed] [Google Scholar]
  15. OJHA K. N., WOOD D. R. The inhibitory effect of stilboestrol on gastric secretion in cats. Br J Pharmacol Chemother. 1950 Sep;5(3):389–394. doi: 10.1111/j.1476-5381.1950.tb00587.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Parbhoo S. P., Johnston I. D. Effects of oestrogens and progestogens on gastric secretion in patients with duodenal ulcer. Gut. 1966 Dec;7(6):612–618. doi: 10.1136/gut.7.6.612. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. TRUELOVE S. C. Stilboestrol, phenobarbitone, and diet in chronic duodenal ulcer. A factorial therapeutic trial. Br Med J. 1960 Aug 20;2(5198):559–566. doi: 10.1136/bmj.2.5198.559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Way S. Gastric Acidity and Hormone Content of Urine in Pregnant Women. Br Med J. 1945 Aug 11;2(4414):182–184. doi: 10.1136/bmj.2.4414.182. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES