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. 1970 Nov;11(11):962–965. doi: 10.1136/gut.11.11.962

Plasma insulin response to oral carbohydrate in patients with glucose and lactose malabsorption

J D Maxwell, Margaret T McKiddie, Anne Ferguson, K D Buchanan
PMCID: PMC1553136  PMID: 5492253

Abstract

Plasma insulin levels were determined following oral glucose in 12 patients with adult coeliac disease, after oral lactose in four patients with alactasia, and in age-matched control subjects.

In coeliac patients the insulin response was greater than expected from the small rise in blood sugar, and no correlation was found between plasma insulin and sugar levels at any period during the test. The separation of the plasma insulin curve from the blood sugar curve after glucose is in keeping with the concept that a factor responsible for stimulating insulin secretion is released from the gut during or after absorption of glucose.

In patients with selective lactose malabsorption (alactasia) administration of lactose by mouth failed to elicit any insulin response, indicating that the insulin-releasing effect of the bowel is not activated merely by the presence of intraluminal carbohydrate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buchanan K. D., McKiddie M. T. The normal insulin response to glucose. The relationship between blood sugar and plasma insulin. Diabetologia. 1967 Oct;3(5):460–464. doi: 10.1007/BF01228083. [DOI] [PubMed] [Google Scholar]
  2. FIELD J. B. FACTORS CONCERNED WITH INSULIN SYNTHESIS AND RELEASE. Metabolism. 1964 May;13:407–421. doi: 10.1016/0026-0495(64)90114-3. [DOI] [PubMed] [Google Scholar]
  3. Ferguson A., Maxwell J. D. Genetic aetiology of lactose intolerance. Lancet. 1967 Jul 22;2(7508):188–190. doi: 10.1016/s0140-6736(67)90009-8. [DOI] [PubMed] [Google Scholar]
  4. HALES C. N., RANDLE P. J. Immunoassay of insulin with insulin-antibody precipitate. Biochem J. 1963 Jul;88:137–146. doi: 10.1042/bj0880137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Holdsworth C. D., Dawson A. M. Glucose and fructose absorption in idiopathic steatorrhoea. Gut. 1965 Aug;6(4):387–391. doi: 10.1136/gut.6.4.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Holdsworth C. D. The gut and oral glucose tolerance. Gut. 1969 Jun;10(6):422–427. doi: 10.1136/gut.10.6.422. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. KALKHOFF R., SCHALCH D. S., WALKER J. L., BECK P., KIPNIS D. M., DAUGHADAY W. H. DIABETOGENIC FACTORS ASSOCIATED WITH PREGNANCY. Trans Assoc Am Physicians. 1964;77:270–280. [PubMed] [Google Scholar]
  8. Love A. H., Canavan D. A. Effects of insulin on intestinal glucose absorption. Lancet. 1968 Dec 21;2(7582):1325–1326. doi: 10.1016/s0140-6736(68)91820-5. [DOI] [PubMed] [Google Scholar]
  9. MCINTYRE N., HOLDSWORTH C. D., TURNER D. S. NEW INTERPRETATION OF ORAL GLUCOSE TOLERANCE. Lancet. 1964 Jul 4;2(7349):20–21. doi: 10.1016/s0140-6736(64)90011-x. [DOI] [PubMed] [Google Scholar]
  10. Malaisse W., Malaisse-Lagae F., Wright P. H. A new method for the measurement in vitro of pancreatic insulin secretion. Endocrinology. 1967 Jan;80(1):99–108. doi: 10.1210/endo-80-1-99. [DOI] [PubMed] [Google Scholar]
  11. Martin F. I., Pearson M. J., Stocks A. E. Glucose tolerance and insulin insensitivity. Lancet. 1968 Jun 15;1(7555):1285–1286. doi: 10.1016/s0140-6736(68)92297-6. [DOI] [PubMed] [Google Scholar]
  12. Mayhew D. A., Wright P. H., Ashmore J. Regulation of insulin secretion. Pharmacol Rev. 1969 Sep;21(3):183–212. [PubMed] [Google Scholar]
  13. McIntyre N., Turner D., Holdsworth D. Liver and oral carbohydrate tolerance. Gut. 1968 Dec;9(6):730–730. [PubMed] [Google Scholar]
  14. YALOW R. S., BERSON S. A. Immunoassay of endogenous plasma insulin in man. J Clin Invest. 1960 Jul;39:1157–1175. doi: 10.1172/JCI104130. [DOI] [PMC free article] [PubMed] [Google Scholar]

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