Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1995 Dec;102(3):603–607. doi: 10.1111/j.1365-2249.1995.tb03859.x

Decreased release of IL-10 by monocytes from patients with lipoid nephrosis.

K Matsumoto 1
PMCID: PMC1553356  PMID: 8536379

Abstract

IL-10, a cross-regulatory cytokine produced by several cell types, including monocytes, is known to stimulate B cell growth and maturation and to inhibit cytokine production. In order to characterize further monocyte function in patients with lipoid nephrosis (LN), the release of IL-10 was measured in supernatants of cultured peripheral blood monocytes (PBM) that were obtained from LN patients and healthy controls. Spontaneous and lipopolysaccharide (LPS)-induced IL-10 release was decreased in patients with LN compared with those in normal controls and lower in LN patients with the nephrotic syndrome (NS) than in those without NS. In contrast, the values in IgA nephropathy (IgAN) patients with or without NS did not differ from normal subjects. There was a negative correlation between IL-10 concentration and the quantity of vascular permeability factor (VPF) released in LN patients. These imply that there is a relative deficit in IL-10 release in active LN, which suggests the possibility that inadequate release of IL-10 may lead to increased VPF activity in active LN patients and the measurements of IL-10 may be of value for monitoring kidney disease. The data provide the first detailed analysis of IL-10 in a group of patients with LN.

Full text

PDF
603

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anttila H. S., Reitamo S., Ceska M., Hurme M. Signal transduction pathways leading to the production of IL-8 by human monocytes are differentially regulated by dexamethasone. Clin Exp Immunol. 1992 Sep;89(3):509–512. doi: 10.1111/j.1365-2249.1992.tb06990.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bhan A. K., Schneeberger E. E., Collins A. B., McCluskey R. T. Evidence for a pathogenic role of a cell-mediated immune mechanism in experimental glomerulonephritis. J Exp Med. 1978 Jul 1;148(1):246–260. doi: 10.1084/jem.148.1.246. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Heslan J. M., Branellec A. I., Pilatte Y., Lang P., Lagrue G. Differentiation between vascular permeability factor and IL-2 in lymphocyte supernatants from patients with minimal-change nephrotic syndrome. Clin Exp Immunol. 1991 Oct;86(1):157–162. doi: 10.1111/j.1365-2249.1991.tb05789.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Howard M., O'Garra A., Ishida H., de Waal Malefyt R., de Vries J. Biological properties of interleukin 10. J Clin Immunol. 1992 Jul;12(4):239–247. doi: 10.1007/BF00918147. [DOI] [PubMed] [Google Scholar]
  5. Johnson K. J., Ward P. A. Role of oxygen metabolites in immune complex injury of lung. J Immunol. 1981 Jun;126(6):2365–2369. [PubMed] [Google Scholar]
  6. Kimata H., Fujimoto M. Growth hormone and insulin-like growth factor I induce immunoglobulin (Ig)E and IgG4 production by human B cells. J Exp Med. 1994 Aug 1;180(2):727–732. doi: 10.1084/jem.180.2.727. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Li L., Elliott J. F., Mosmann T. R. IL-10 inhibits cytokine production, vascular leakage, and swelling during T helper 1 cell-induced delayed-type hypersensitivity. J Immunol. 1994 Nov 1;153(9):3967–3978. [PubMed] [Google Scholar]
  8. Matsumoto K. Decreased production of interleukin-1 by monocytes from patients with lipoid nephrosis. Clin Nephrol. 1989 Jun;31(6):292–296. [PubMed] [Google Scholar]
  9. Matsumoto K., Okano K., Yoshizawa N., Harada M., Ohi H., Hatano M. Impaired T-lymphocyte colony formation in lipoid nephrosis. Clin Nephrol. 1985 Dec;24(6):279–284. [PubMed] [Google Scholar]
  10. Matsumoto K., Osakabe K., Katayama H., Okano K., Hatano M. Defective cell-mediated immunity in lipoid nephrosis. Int Arch Allergy Appl Immunol. 1984;73(4):370–372. doi: 10.1159/000233501. [DOI] [PubMed] [Google Scholar]
  11. Shalhoub R. J. Pathogenesis of lipoid nephrosis: a disorder of T-cell function. Lancet. 1974 Sep 7;2(7880):556–560. doi: 10.1016/s0140-6736(74)91880-7. [DOI] [PubMed] [Google Scholar]
  12. Vissers M. C., Fantone J. C., Wiggins R., Kunkel S. L. Glomerular basement membrane-containing immune complexes stimulate tumor necrosis factor and interleukin-1 production by human monocytes. Am J Pathol. 1989 Jan;134(1):1–6. [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES