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. 1972 Oct;12(2):185–193.

The multiple occurrence of myeloma and asymptomatic paraproteinaemia within one family

Katharina A E Meijers, B de Leeuw, Milena Voormolen-Kálova
PMCID: PMC1553574  PMID: 4567645

Abstract

Case histories are described of three patients who died of myeloma and of three persons with asymptomatic paraproteinaemia. They were first and second degree relatives in two generations of a Dutch family without consanguinity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AXELSSON U., HALLEN J. FAMILIAL OCCURRENCE OF PATHOLOGICAL SERUM-PROTEINS OF DIFFERENT GAMMA-GLOBULIN GROUPS. Lancet. 1965 Aug 21;2(7408):369–370. doi: 10.1016/s0140-6736(65)90344-2. [DOI] [PubMed] [Google Scholar]
  2. Alexander L. L., Benninghoff D. L. Familial multiple myeloma. J Natl Med Assoc. 1965 Nov;57(6):471–475. [PMC free article] [PubMed] [Google Scholar]
  3. Axelsson U., Bachmann R., Hällén J. Frequency of pathological proteins (M-components) om 6,995 sera from an adult population. Acta Med Scand. 1966 Feb;179(2):235–247. doi: 10.1111/j.0954-6820.1966.tb05453.x. [DOI] [PubMed] [Google Scholar]
  4. Berlin S. O., Odeberg H., Weingart L. Familial occurrence of M-components. Acta Med Scand. 1968 Apr;183(4):347–350. doi: 10.1111/j.0954-6820.1968.tb10489.x. [DOI] [PubMed] [Google Scholar]
  5. CASE RECORDS of the Massachusetts General Hospital; case 45261. N Engl J Med. 1959 Jun 25;260(26):1336–1342. doi: 10.1056/NEJM195906252602611. [DOI] [PubMed] [Google Scholar]
  6. GROSSMAN L. A., OWNBY F. D., GROSSMAN M., KAPLAN H. J., WOLFE L. K. MULTIPLE MYELOMA IN BROTHERS. J Tenn Med Assoc. 1963 Oct;56:398–400. [PubMed] [Google Scholar]
  7. Grant J. A., Blumenschein G. R., Buckley C. E., 3rd Familial paraproteinemia. Arch Intern Med. 1971 Sep;128(3):427–431. [PubMed] [Google Scholar]
  8. HALLEN J. Frequency of "abnormal" serum globulins (M-components) in the aged. Acta Med Scand. 1963 Jun;173:737–744. [PubMed] [Google Scholar]
  9. HERRELL W. E., RUFF J. D., BAYRD E. D. Multiple myeloma in siblings. J Am Med Assoc. 1958 Jul 19;167(12):1485–1487. doi: 10.1001/jama.1958.72990290003009a. [DOI] [PubMed] [Google Scholar]
  10. HIRSCH W., SCHWARZ G. [Multiple myeloma in siblings (contribution to the diagnosis, clinical aspects and etiology of plasmocytoma)]. Med Klin. 1959 Sep 4;54:1624–1626. [PubMed] [Google Scholar]
  11. Kalff M. W., Hijmans W. Immunoglobulin analysis in families of macroglobulinaemia patients. Clin Exp Immunol. 1969 Nov;5(5):479–498. [PMC free article] [PubMed] [Google Scholar]
  12. Kalff M. W. Quantitative determination of serum immunoglobulin levels by single radial immunodiffusion. Clin Biochem. 1970 Mar;3(1):91–104. [PubMed] [Google Scholar]
  13. LARSSON S. O. Myeloma and pernicious anaemia. Acta Med Scand. 1962 Aug;172:195–205. doi: 10.1111/j.0954-6820.1962.tb07143.x. [DOI] [PubMed] [Google Scholar]
  14. LEONCINI D. L. KORNGOLD L: MULTIPLE MYELOMA IN 2 SISTERS. AN IMMUNOCHEMICAL STUDY. Cancer. 1964 Jun;17:733–737. doi: 10.1002/1097-0142(196406)17:6<733::aid-cncr2820170608>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  15. LIMARZI L. R. Diagnostic and therapeutic aspects of multiple myeloma. Med Clin North Am. 1951 Jan;35(1):189–226. [PubMed] [Google Scholar]
  16. MANDEMA E., WILDERVANCK L. S. La maladie de Kahler (myélomes multiples) chez deux soeurs. J Genet Hum. 1954 Oct;3(3):170–175. [PubMed] [Google Scholar]
  17. MANSON D. I. Multiple myeloma in sisters. Scott Med J. 1961 May;6:188–188. doi: 10.1177/003693306100600502. [DOI] [PubMed] [Google Scholar]
  18. Manigand G., Sarrazin A., Demuth L., Schoen E., Deparis M., Ropartz C., Rivat L. Maladie de Kahler familiale. Etude immunologique et caryotypique d'une observation. Presse Med. 1970 Sep 26;78(40):1741–1743. [PubMed] [Google Scholar]
  19. NADEAU L. A., MAGALINI S. I., STEFANINI M. Familial multiple myeloma. AMA Arch Pathol. 1956 Feb;61(2):101–106. [PubMed] [Google Scholar]
  20. Petite J., Cruchaud A. Qualitative and quantitative abnormalities of immunoglobulins in relatives of patients with idiopathic paraprotenemia. A study of 12 families. Helv Med Acta. 1970 Oct;35(4):248–265. [PubMed] [Google Scholar]
  21. Robbins R. Familial multiple myeloma: the tenth reported occurrence. Am J Med Sci. 1967 Dec;254(6):848–850. doi: 10.1097/00000441-196712000-00012. [DOI] [PubMed] [Google Scholar]
  22. Rádl J. Light chain typing of immunoglobulins in small samples of biological material. Immunology. 1970 Jul;19(1):137–149. [PMC free article] [PubMed] [Google Scholar]
  23. THOMAS T. F. MULTIPLE MYELOMA IN SIBLINGS. N Y State J Med. 1964 Aug 15;64:2096–2099. [PubMed] [Google Scholar]
  24. Williams R. C., Jr, Erickson J. L., Polesky H. F., Swaim W. R. Studies of monoclonal immunoglobulins (M-components) in various kindreds. Ann Intern Med. 1967 Aug;67(2):309–327. doi: 10.7326/0003-4819-67-2-309. [DOI] [PubMed] [Google Scholar]
  25. van Furth R., Schuit H. R., Hijmans W. The formation in vitro of paraproteins in multiple myeloma and Waldenström's macroglobulinaemia. Br J Haematol. 1966 Mar;12(2):202–211. doi: 10.1111/j.1365-2141.1966.tb05626.x. [DOI] [PubMed] [Google Scholar]

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