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. 1972 Oct;12(2):177–184.

IgG antigens of the Cγ2 and Cγ3 homology regions interacting with rheumatoid factors

J B Natvig, P I Gaarder, M W Turner
PMCID: PMC1553578  PMID: 4648819

Abstract

Haemagglutination inhibition experiments were used to study the interaction of several well-defined rheumatoid factors with pFc' fragments (≡Cγ3 homology regions) prepared from all four IgG subclasses. The results suggest that rheumatoid factors interact with antigens located in both homology regions of the Fc fragment. A minimum of four reactive regions is suggested—one in the Cγ3 region and three more in the Cγ2 region. This multiplicity of IgG antigens may contribute to the formation of rheumatoid factor-IgG complexes and therefore play a role in the complement-fixing activity of such complexes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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