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. 1972 Oct;12(2):161–169.

Antigen-binding lymphocytes in children with immune deficiency

J M Dwyer, C S Hosking
PMCID: PMC1553583  PMID: 4630777

Abstract

Twenty-one patients with suspected immunodeficiency were studied for serum immunoglobulin levels, antibodies to flagellin and flagellin-binding lymphocytes before and after immunization, and the lymphocyte response to phytohaemagglutinin (PHA).

Seven of eight children with sex-linked agammaglobulinaemia failed to produce antibody after immunization with flagellin and in six no flagellin-binding lymphocytes were detected; seven had an abnormal PHA response. Four subjects with acquired agammaglobulinaemia had a normal increase in flagellin-binding lymphocytes after immunization despite little or no production of antibody to flagellin.

It is suggested that sex-linked agammaglobulinaemia is a B cell defect in antigen recognition, due to the absence of lymphocyte surface receptors whereas the lesion in acquired agammaglobulinaemia is in the B cell effector apparatus. In children with selective immunoglobulin deficiency (IgA) and with immunodeficiency and ataxia telangiectasia, defects of flagellin-binding cells and antibody were noted.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADA G. L., NOSSAL G. J., PYE J., ABBOT A. ANTIGENS IN IMMUNITY. I. PREPARATION AND PROPERTIES OF FLAGELLAR ANTIGENS FROM SALMONELLA ADELAIDE. Aust J Exp Biol Med Sci. 1964 Jun;42:267–282. [PubMed] [Google Scholar]
  2. BARON S., NASOU J. P., FRIEDMAN R. M., OWEN G. M., LEVY H. B., BARNETT E. V. Antibody production by hypogammaglobulinemic patients. J Immunol. 1962 Apr;88:443–449. [PubMed] [Google Scholar]
  3. Blaese R. M., Strober W., Brown R. S., Waldmann T. A. The Wiskott-Aldrich syndrome. A disorder with a possible defect in antigen processing or recognition. Lancet. 1968 May 18;1(7551):1056–1061. doi: 10.1016/s0140-6736(68)91411-6. [DOI] [PubMed] [Google Scholar]
  4. Buckley R. H., Dees S. C., O'Fallon W. M. Serum immunoglobulins. I. Levels in normal children and in uncomplicated childhood allergy. Pediatrics. 1968 Mar;41(3):600–611. [PubMed] [Google Scholar]
  5. Ching Y. C., Davis S. D., Wedgwood R. J. Antibody studies in hypogammaglobulinemia. J Clin Invest. 1966 Oct;45(10):1593–1600. doi: 10.1172/JCI105465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cooper M. D., Lawton A. R., Bockman D. E. Agammaglobulinaemia with B lymphocytes. Specific defect of plasma-cell differentiation. Lancet. 1971 Oct 9;2(7728):791–794. doi: 10.1016/s0140-6736(71)92742-5. [DOI] [PubMed] [Google Scholar]
  7. Dwyer J. M., Mackay I. R. Antigen-binding lymphocytes in human blood. Lancet. 1970 Jan 24;1(7639):164–167. doi: 10.1016/s0140-6736(70)90406-x. [DOI] [PubMed] [Google Scholar]
  8. Dwyer J. M., Mackay I. R. Antigen-binding lymphocytes in human fetal thymus. Lancet. 1970 Jun 6;1(7658):1199–1202. doi: 10.1016/s0140-6736(70)91787-3. [DOI] [PubMed] [Google Scholar]
  9. Fitzgerald M. G. The establishment of a normal human population dose-response curve for lymphocytes cultured with PHA (phytohaemagglutinin). Clin Exp Immunol. 1971 Mar;8(3):421–425. [PMC free article] [PubMed] [Google Scholar]
  10. Fudenberg H. H., Good R. A., Hitzig W., Kunkel H. G., Roitt I. M., Rosen F. S., Rowe D. S., Seligmann M., Soothill J. R. Classification of the primary immune deficiencies: WHO recommendation. N Engl J Med. 1970 Sep 17;283(12):656–657. doi: 10.1056/NEJM197009172831211. [DOI] [PubMed] [Google Scholar]
  11. Gleich G. J., Uhr J. W., Vaughan J. H., Swedlund H. A. Antibody formation in dysgammaglobulinemia. J Clin Invest. 1966 Aug;45(8):1334–1340. doi: 10.1172/JCI105440. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hosking C. S., Fitzgerald M. G., Simons M. J. Quantified deficiency of lymphocyte response to phytohaemagglutinin in immune deficiency diseases. Clin Exp Immunol. 1971 Oct;9(4):467–476. [PMC free article] [PubMed] [Google Scholar]
  13. Lieber E., Hirschhorn K., Fudenberg H. H. Response of agammaglobulinaemic lymphocytes in mixed lymphocyte culture. Clin Exp Immunol. 1969 Jan;4(1):83–91. [PMC free article] [PubMed] [Google Scholar]
  14. Miller J. F., Basten A., Sprent J., Cheers C. Interaction between lymphocytes in immune responses. Cell Immunol. 1971 Oct;2(5):469–495. doi: 10.1016/0008-8749(71)90057-8. [DOI] [PubMed] [Google Scholar]
  15. Naor D., Bentwich Z., Cividalli G. Inability of peripheral lymphoid cells of agammaglobulinaemic patients to bind radioiodinated albumins. Aust J Exp Biol Med Sci. 1969 Dec;47(6):759–761. doi: 10.1038/icb.1969.173. [DOI] [PubMed] [Google Scholar]
  16. Rocklin R. E., Rosen F. S., David J. R. In vitro lymphocyte response of patients with immunologic deficiency diseases. N Engl J Med. 1970 Jun 11;282(24):1340–1343. doi: 10.1056/NEJM197006112822404. [DOI] [PubMed] [Google Scholar]
  17. Rowley M. J., Mackay I. R. Measurement of antibody-producing capacity in man. I. The normal response to flagellin from Salmonella adelaide. Clin Exp Immunol. 1969 Oct;5(4):407–418. [PMC free article] [PubMed] [Google Scholar]

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