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. 1972 Jun;11(2):265–276.

Studies on drug induced lupus erythematosus in mice. I. Drug induced antinuclear antibodies (ANA)

J H Ten Veen, T E W Feltkamp
PMCID: PMC1553628  PMID: 4557182

Abstract

Hydralazin, isoniazid, procainamide, α-methyldopa and chlorthalidone were given orally to mice of three inbred strains: BALB/CJ, C57/BL/6J and A/JAX. All drugs significantly increased the frequency of antinuclear antibodies (ANA). The results were most marked after 8 months of treatment. Although a slight preponderance of females was observed for ANA frequencies in BALB/CJ and A/JAX mice, this was significant only for hydralazin- and procainamide-treated animals. C57/BL/6J males appeared to respond better than females. Genetical factors appear of importance in the induciton of drug induced lupus erythematosus (DILE).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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