Skip to main content
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1972 Jun;11(2):201–207.

The concetrations of the fourth component of complement and of the C[unk] inactivator in synovial fluid from arthritic patients

H Hedberg, Anna-Brita Laurell
PMCID: PMC1553630  PMID: 5040309

Abstract

The concentration of the fourth component (C4) of complement (C) in synovial fluid was immunochemically determined in forty-nine cases of arthritis. The lowest C4 values were found in the patients with rheumatoid arthritis (RA), in particular those with depressed synovial fluid C values (and positive rheumatoid factor tests), whereas the highest were obtained in cases of non-rheumatoid arthritis (pelvospondylites ossificans, Reiter's disease and psoriasis arthropathica) and in the majority of the sero-negative RA patients. Low C4 values also proved closely associated with low values for the third component (C3), and with pronounced conversion of this component. The C[unk] inactivator (immunochemically determined) of the synovial fluid which was correlated with the albumin concentration, did not vary with total C, C4 or C3.

Full text

PDF
201

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dias Da Silva W., Lepow I. H. Complement as a mediator of inflammation. II. Biological properties of anaphylatoxin prepared with purified components of human complement. J Exp Med. 1967 May 1;125(5):921–946. doi: 10.1084/jem.125.5.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Gormsen J., Andersen R. B., Feddersen C. Fibrinogen-fibrin breakdown products in pathologic synovial fluids. An immunologic study. Arthritis Rheum. 1971 Jul-Aug;14(4):503–512. doi: 10.1002/art.1780140410. [DOI] [PubMed] [Google Scholar]
  3. Götze O., Müller-Eberhard H. J. Lysis of erythrocytes by complement in the absence of antibody. J Exp Med. 1970 Nov;132(5):898–915. doi: 10.1084/jem.132.5.898. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HEDBERG H. THE DEPRESSED SYNOVIAL COMPLEMENT ACTIVITY IN ADULT AND JUVENILE RHEUMATOID ARTHRITIS. Acta Rheumatol Scand. 1964;10:109–127. doi: 10.3109/rhe1.1964.10.issue-1-4.11. [DOI] [PubMed] [Google Scholar]
  5. Hedberg H., Lundh B., Laurell A. B. Studies of the third component of complement in synovial fluid from arthritic patients. II. Conversion and its relation to total complement. Clin Exp Immunol. 1970 May;6(5):707–712. [PMC free article] [PubMed] [Google Scholar]
  6. LAURELL C. B. ANTIGEN-ANTIBODY CROSSED ELECTROPHORESIS. Anal Biochem. 1965 Feb;10:358–361. doi: 10.1016/0003-2697(65)90278-2. [DOI] [PubMed] [Google Scholar]
  7. Laurell A. B. Effect of trypsin on complement components in normal human serum. Acta Pathol Microbiol Scand. 1968;72(1):139–146. doi: 10.1111/j.1699-0463.1968.tb00441.x. [DOI] [PubMed] [Google Scholar]
  8. Laurell A. B., Lindegren J., Malmros I., Mårtensson H. Enzymatic and immunochemical estimation of C'1 esterase inhibitor in sera from patients with hereditary angioneurotic edema. Scand J Clin Lab Invest. 1969 Oct;24(3):221–225. doi: 10.3109/00365516909080156. [DOI] [PubMed] [Google Scholar]
  9. Laurell A. B., Sjöholm A., Johnson U. Quantitation of the fourth complement component by electrophoresis in agarose gel containing antibodies. Clin Exp Immunol. 1970 Sep;7(3):423–430. [PMC free article] [PubMed] [Google Scholar]
  10. Lundh B., Hedberg H., Laurell A. B. Studies of the third component of complement in synovial fluid from arthritic patients. Clin Exp Immunol. 1970 Mar;6(3):407–411. [PMC free article] [PubMed] [Google Scholar]
  11. Müller-Eberhard H. J. Complement. Annu Rev Biochem. 1969;38:389–414. doi: 10.1146/annurev.bi.38.070169.002133. [DOI] [PubMed] [Google Scholar]
  12. Natvig J. B., Winchester R. J. Complement in rheumatoid inflammation. Acta Rheumatol Scand. 1969;15(3):161–168. doi: 10.3109/rhe1.1969.15.issue-1-4.24. [DOI] [PubMed] [Google Scholar]
  13. RATNOFF O. D., LEPOW I. H. Some properties of an esterase derived from preparations of the first component of complement. J Exp Med. 1957 Aug 1;106(2):327–343. doi: 10.1084/jem.106.2.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ratnoff O. D., Naff G. B. The conversion of C'IS to C'1 esterase by plasmin and trypsin. J Exp Med. 1967 Feb 1;125(2):337–358. doi: 10.1084/jem.125.2.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Ruddy S., Austen K. F. The complement system in rheumatoid synovitis. I. An analysis of complement component activities in rheumatoid synovial fluids. Arthritis Rheum. 1970 Nov-Dec;13(6):713–723. doi: 10.1002/art.1780130601. [DOI] [PubMed] [Google Scholar]
  16. Thompson R. A., Lachmann P. J. Reactive lysis: the complement-mediated lysis of unsensitized cells. I. The characterization of the indicator factor and its identification as C7. J Exp Med. 1970 Apr 1;131(4):629–641. doi: 10.1084/jem.131.4.629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Winchester R. J., Agnello V., Kunkel H. G. Gamma globulin complexes in synovial fluids of patients with rheumatoid arthritis. Partial characterization and relationship to lowered complement levels. Clin Exp Immunol. 1970 May;6(5):689–706. [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES