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. 1972 Sep;12(1):21–30.

Serum complement after orthotopic transplantation of the human liver

M Torisu, T Yokoyama, P F Kohler, A L Durst, G Martineau, G Schroter, H Amemiya, C G Groth, T E Starzl
PMCID: PMC1553651  PMID: 4628404

Abstract

In five patients with terminal liver failure, replacement of the diseased liver with a well functioning homograft restored markedly depressed total complement and C4 and C3 to normal levels. Concomitantly, C5 protein also increased. Postoperatively, two patients developed a marked drop in C4 and C3 probably in relation to homograft rejection. In contrast, serum hepatitis and biliary obstruction were not accompanied by significant changes. It is concluded that the liver is an important source of synthesis of C4, C3 and C5 and that complement assays might aid in otherwise equivocal diagnosis of hepatic homograft rejection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alper C. A., Johnson A. M., Birtch A. G., Moore F. D. Human C'3: evidence for the liver as the primary site of synthesis. Science. 1969 Jan 17;163(3864):286–288. doi: 10.1126/science.163.3864.286. [DOI] [PubMed] [Google Scholar]
  2. Alpert E., Isselbacher K. J., Schur P. H. The pathogenesis of arthritis associated with viral hepatitis. Complement-component studies. N Engl J Med. 1971 Jul 22;285(4):185–189. doi: 10.1056/NEJM197107222850401. [DOI] [PubMed] [Google Scholar]
  3. Borsos T., Rapp H. J. Immune hemolysis: a simplified method for the preparation of EAC'4 with guinea pig or with human complement. J Immunol. 1967 Aug;99(2):263–268. [PubMed] [Google Scholar]
  4. Carpenter C. B., Gill T. J., 3rd, Merrill J. P., Dammin G. J. Alterations in human serum beta-1C-gobulin (C'3) in renal transplantation. Am J Med. 1967 Dec;43(6):854–867. doi: 10.1016/0002-9343(67)90244-6. [DOI] [PubMed] [Google Scholar]
  5. Hanauer L. B., Christian C. L. Clinical studies of hemolytic complement and the 11S component. Am J Med. 1967 Jun;42(6):882–890. doi: 10.1016/0002-9343(67)90069-1. [DOI] [PubMed] [Google Scholar]
  6. Inai S., Fujikawa K., Nagaki K., Ozono N., Ishida S. Serum level of the fourth component of complement in various diseases. Biken J. 1967 Jun;10(2):65–87. [PubMed] [Google Scholar]
  7. Inoue K., Nelson R. A., Jr The isolation and characterization of a new component of hemolytic complement, C'3e. J Immunol. 1965 Aug;95(2):355–367. [PubMed] [Google Scholar]
  8. JORDAN F. L. J. The significance of the complement test in liver diseases with jaundice. Acta Med Scand. 1953;144(4):268–274. doi: 10.1111/j.0954-6820.1953.tb15696.x. [DOI] [PubMed] [Google Scholar]
  9. Johnson A. M., Alper C. A., Rosen F. S., Craig J. M. C1 inhibitor: evidence for decreased hepatic synthesis in hereditary angioneurotic edema. Science. 1971 Aug 6;173(3996):553–554. doi: 10.1126/science.173.3996.553. [DOI] [PubMed] [Google Scholar]
  10. Kohler P. F., Müller-Eberhard H. J. Immunochemical quantitation of the third, fourth and fifth components of human complement: concentrations in the serum of healthy adults. J Immunol. 1967 Dec;99(6):1211–1216. [PubMed] [Google Scholar]
  11. Kohler P. F., Ten Bensel R. Serial complement component alterations in acute glomerulonephritis and systemic lupus erythematosus. Clin Exp Immunol. 1969 Feb;4(2):191–202. [PMC free article] [PubMed] [Google Scholar]
  12. LEPOW I. H., NAFF G. B., TODD E. W., PENSKY J., HINZ C. F. Chromatographic resolution of the first component of human complement into three activities. J Exp Med. 1963 Jun 1;117:983–1008. doi: 10.1084/jem.117.6.983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. MANDEL E. E., LANGE K. Serum complement in hepatobiliary diseases. Proc Soc Exp Biol Med. 1955 Dec;90(3):606–608. doi: 10.3181/00379727-90-22111. [DOI] [PubMed] [Google Scholar]
  14. MUELLER-EBERHARD H. J., BIRO C. E. ISOLATION AND DESCRIPTION OF THE FOURTH COMPONENT OF HUMAN COMPLEMENT. J Exp Med. 1963 Sep 1;118:447–466. doi: 10.1084/jem.118.3.447. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  16. NILSSON U. R., MUELLER-EBERHARD H. J. ISOLATION OF BETA IF-GLOBULIN FROM HUMAN SERUM AND ITS CHARACTERIZATION AS THE FIFTH COMPONENT OF COMPLEMENT. J Exp Med. 1965 Aug 1;122:277–298. doi: 10.1084/jem.122.2.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. NISHIOKA K., LINSCOTT W. D. COMPONENTS OF GUINEA PIG COMPLEMENT. I. SEPARATION OF A SERUM FRACTION ESSENTIAL FOR IMMUNE HEMOLYSIS AND IMMUNE ADHERENCE. J Exp Med. 1963 Nov 1;118:767–793. doi: 10.1084/jem.118.5.767. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. NISHIOKA K. Measurements of complement by agglutination of human erythrocytes reacting in immune-adherence. J Immunol. 1963 Jan;90:86–97. [PubMed] [Google Scholar]
  19. Nelson R. A., Jr, Jensen J., Gigli I., Tamura N. Methods for the separation, purification and measurement of nine components of hemolytic complement in guinea-pig serum. Immunochemistry. 1966 Mar;3(2):111–135. doi: 10.1016/0019-2791(66)90292-8. [DOI] [PubMed] [Google Scholar]
  20. SEVER J. L. Application of a microtechnique to viral serological investigations. J Immunol. 1962 Mar;88:320–329. [PubMed] [Google Scholar]
  21. Starzl T. E., Halgrimson C. G., Penn I., Martineau G., Schroter G., Amemiya H., Putnam C. W., Groth C. G. Cyclophosphamide and human organ transplantation. Lancet. 1971 Jul 10;2(7715):70–74. doi: 10.1016/s0140-6736(71)92046-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Torisu M., Yokoyama T., Amemiya H., Kohler P. F., Schroter G., Martineau G., Penn I., Palmer W., Halgrimson C. G., Putnam C. W. Immunosuppression, liver injury, and hepatitis in renal, hepatic, and cardiac homograft recipients: with particular reference to the Australia antigen. Ann Surg. 1971 Oct;174(4):620–639. doi: 10.1097/00000658-197110000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]

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