Abstract
Rats injected with syngeneic chondrocytes or cartilage shavings develop autoreactivity as assayed by the leucocyte migration inhibition test. It is suggested that chondrocyte specific differentiation antigen(s), normally sequestered from the immune system, once exposed experimentally by enzyme treatment or in some human pathological situations are recognized as foreign immunogens and induce a lymphocyte response.
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Selected References
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- Ali S. Y., Sajdera S. W., Anderson H. C. Isolation and characterization of calcifying matrix vesicles from epiphyseal cartilage. Proc Natl Acad Sci U S A. 1970 Nov;67(3):1513–1520. doi: 10.1073/pnas.67.3.1513. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bentley G., Greer R. B., 3rd Homotransplantation of isolated epiphyseal and articular cartilage chondrocytes into joint surfaces of rabbits. Nature. 1971 Apr 9;230(5293):385–388. doi: 10.1038/230385a0. [DOI] [PubMed] [Google Scholar]
- Chesterman P. J., Smith A. U. Homotransplantation of articular cartilage and isolated chondrocytes. An experimental study in rabbits. J Bone Joint Surg Br. 1968 Feb;50(1):184–197. [PubMed] [Google Scholar]
- DAVIS W. B., GIBSON T. Absorption of autogenous cartilage grafts in man. Br J Plast Surg. 1956 Oct;9(3):177–185. doi: 10.1016/s0007-1226(56)80032-5. [DOI] [PubMed] [Google Scholar]
- Falk R. E., Thorsby E., Möller E., Möller G. In vitro assay of cell-mediated immunity: the inhibition of migration of sensitized human lymphocytes by HL-A antigens. Clin Exp Immunol. 1970 Apr;6(4):445–455. [PMC free article] [PubMed] [Google Scholar]
- Harris E. D., Jr, Evanson J. M., DiBona D. R., Krane S. M. Collagenase and rheumatoid arthritis. Arthritis Rheum. 1970 Jan-Feb;13(1):83–94. doi: 10.1002/art.1780130109. [DOI] [PubMed] [Google Scholar]
- Heyner S. The significance of the intercellular matrix in the survival of cartilage allografts. Transplantation. 1969 Nov;8(5):666–677. doi: 10.1097/00007890-196911000-00011. [DOI] [PubMed] [Google Scholar]
- Lemperg R. Studies of autologous diced costal cartilage transplant. I. The morphological changes and 35S-sulphate uptake in vitro after intramuscular implantation. Acta Soc Med Ups. 1967;72(3):120–140. [PubMed] [Google Scholar]
- McKibbin B., Holdsworth F. W. The dual nature of epiphysial cartilage. J Bone Joint Surg Br. 1967 May;49(2):351–361. [PubMed] [Google Scholar]
- Medoff J. Enzymatic events during cartilage differentiation in the chick embryonic limb bud. Dev Biol. 1967 Aug;16(2):118–143. doi: 10.1016/0012-1606(67)90020-6. [DOI] [PubMed] [Google Scholar]
- Moskalewski S., Kawiak J. Cartilage formation after homotransplantation of isolated chondrocytes. Transplantation. 1965 Nov;3(6):737–747. doi: 10.1097/00007890-196511000-00005. [DOI] [PubMed] [Google Scholar]
- Soborg M., Bendixen G. Human lymphocyte migration as a parameter of hypersensitivity. Acta Med Scand. 1967 Feb;181(2):247–256. doi: 10.1111/j.0954-6820.1967.tb07255.x. [DOI] [PubMed] [Google Scholar]
- Westhues M. Die antigene Wirkung des Knorpels. 4. Die Möglichkeit der Autoimmunerkrankung des Knorpels. Z Laryngol Rhinol Otol. 1971 Jan;50(1):49–56. [PubMed] [Google Scholar]
