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. 1972 May;11(1):143–149.

A two-stage model for development of antibody-producing cells

M D Cooper, A R Lawton, P W Kincade
PMCID: PMC1553675  PMID: 5064586

Abstract

This model divides plasma cell differentiation into two developmental stages within the framework of the clonal selection theory. The first stage occurs within specific induction micro-environments, independently of foreign antigens, and involves the generation of multiple clones of B-lymphocytes from stem cells of haematogenous origin. During this stage, diversity of immunoglobulin classes is generated by an orderly intraclonal switch from IgM to IgG to IgA; the antibodies made are incorporated into the cell surface. The second stage occurs in the circulation and in peripheral lymphoid tissues; it involves clonal selection of B-lymphocytes by antigens with subsequent proliferation and differentiation to become either memory cells or antibody-producing plasma cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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