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. 1972 May;11(1):37–42.

Antigen–antibody induced cutaneous eosinophilia in complement deficient guinea-pigs

A B Kay, K F Austen
PMCID: PMC1553680  PMID: 5038772

Abstract

Decomplementation with cobra venom factor had no effect on eosinophil accumulation into the site of IgG1-mediated PCA reactions in the guinea-pig. Eosinophil and neutrophil accumulation also followed PCA reactions in animals partially or totally deficient in C4.

The effect of intradermal injections of pre-formed antigen–antibody complexes prepared from guinea-pig IgG1 or IgG2 were not affected by decomplementation with cobra venom. The lesions produced with either immunoglobulin complex were similar in appearance in decomplemented and normal animals and were followed by comparable tissue accumulation of eosinophils and neutrophils.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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