Abstract
The effect of 600 r of γ-radiation on NZB/W and stock mice was studied. In both groups of mice more than 50% of the animals died from thymomas and a small percentage from other tumours. The deaths from thymomas occurred significantly earlier than the deaths from other tumours. The time of onset and incidence of autoimmunity in the NZB/W mice did not appear to be affected by the treatment. The stock mice developed no autoimmunity.
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- BIELSCHOWSKY M., BIELSCHOWSKY F. Reaction of the reticular tissue of mice with autoimmune haemolytic anaemia to 2-aminofluorene. Nature. 1962 May 19;194:692–692. doi: 10.1038/194692a0. [DOI] [PubMed] [Google Scholar]
- Casey T. P. The development of lymphomas in mice with autoimmune disorders treated with azathioprine. Blood. 1968 Mar;31(3):396–399. [PubMed] [Google Scholar]
- HOLMES M. C., BURNET F. M. THE NATURAL HISTORY OF AUTOIMMUNE DISEASE IN NZB MICE. A COMPARISON WITH THE PATTERN OF HUMAN AUTOIMMUNE MANIFESTATIONS. Ann Intern Med. 1963 Sep;59:265–276. doi: 10.7326/0003-4819-59-3-265. [DOI] [PubMed] [Google Scholar]
- Howie J. B., Helyer B. J. The immunology and pathology of NZB mice. Adv Immunol. 1968;9:215–266. doi: 10.1016/s0065-2776(08)60444-7. [DOI] [PubMed] [Google Scholar]
- Kaplan H. S. On the natural history of the murine leukemias: presidential address. Cancer Res. 1967 Aug;27(8):1325–1340. [PubMed] [Google Scholar]
- SEARCY R. L., GOUGH G. S., KOROTZER J. L., BERGQUIST L. M. Evaluation of a new technique for estimation of urea nitrogen in serum. Am J Med Technol. 1961 Sep-Oct;27:255–262. [PubMed] [Google Scholar]