Abstract
Antibodies to native human collagen were detected by passive haemagglutination in the serum of sixteen of thirty-six subjects with selective TgA deficiency (44·4%), compared to 2·5% of control subjects. The sixteen subjects with anti-collagen antibodies inculded four asymptomatic subjects, five with recurrent infections, four with ataxia telangiectasia, and one each with lymphoma, asthma, and rheumatoid arthritis. There was no statistically significant correlation in individual subjects between the presence of anti-collagen antibodies and antibodies to human IgG, IgA, IgM and ruminant proteins.
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Selected References
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- Ammann A. J., Hong R. Selective IgA deficiency: presentation of 30 cases and a review of the literature. Medicine (Baltimore) 1971 May;50(3):223–236. [PubMed] [Google Scholar]
- Ammann A. J., Hong R. Unique antibody to basement membrane in patients with selective IgA deficiency and coeliac disease. Lancet. 1971 Jun 19;1(7712):1264–1266. doi: 10.1016/s0140-6736(71)91779-x. [DOI] [PubMed] [Google Scholar]
- Bachmann R. Studies on the serum gamma-A-globulin level. 3. The frequency of A-gamma-A-globulinemia. Scand J Clin Lab Invest. 1965;17(4):316–320. doi: 10.3109/00365516509077057. [DOI] [PubMed] [Google Scholar]
- Beutner E. H., Jordon R. E., Chorzelski T. P. The immunopathology of pemphigus and bullous pemphigoid. J Invest Dermatol. 1968 Aug;51(2):63–80. [PubMed] [Google Scholar]
- Brandtzaeg P. Human secretory immunoglobulins. II. Salivary secretions from individuals with selectively excessive or defective synthesis of serum immunoglobulins. Clin Exp Immunol. 1971 Jan;8(1):69–85. [PMC free article] [PubMed] [Google Scholar]
- Collins-Williams C., Kokubu H. L., Lamenza C., Nizami R., Chiu A. W., Lewis-McKinley C., Comerford T. A., Varga E. A. Incidence of isolated deficiency of IgA in the serum of Canadian children. Ann Allergy. 1972 Jan;30(1):11–23. [PubMed] [Google Scholar]
- Ferguson A., Carswell F. Precipitins to dietary proteins in serum and upper intestinal secretions of coeliac children. Br Med J. 1972 Jan 8;1(5792):75–77. doi: 10.1136/bmj.1.5792.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fudenberg H. H., Gold E. R., Vyas G. N., Mackenzie M. R. Human antibodies to human IgA globulins. Immunochemistry. 1968 Mar;5(2):203–206. doi: 10.1016/0019-2791(68)90103-1. [DOI] [PubMed] [Google Scholar]
- Furthmayr H., Beil W., Timpl R. Different antigenic determinants in the polypeptide chains of human collagen. FEBS Lett. 1971 Feb 9;12(6):341–344. doi: 10.1016/0014-5793(71)80010-8. [DOI] [PubMed] [Google Scholar]
- Kenrick K. G., Walker-Smith J. A. Immunoglobulins and dietary protein antibodies in childhood coeliac disease. Gut. 1970 Aug;11(8):635–640. doi: 10.1136/gut.11.8.635. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lindqvist K. J., Osterland C. K. Human antibodies to vascular endothelium. Clin Exp Immunol. 1971 Dec;9(6):753–760. [PMC free article] [PubMed] [Google Scholar]
- Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
- McPhaul J. J., Jr, Dixon F. J. Characterization of human anti-glomerular basement membrane antibodies eluted from glomerulonephritic kidneys. J Clin Invest. 1970 Feb;49(2):308–317. doi: 10.1172/JCI106240. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Michaeli D., Benjamini E., Leung D. Y., Martin G. R. Immunochemical studies on collagen. II. Antigenic differences between guinea pig skin collagen and gelatin. Immunochemistry. 1971 Jan;8(1):1–6. doi: 10.1016/0019-2791(71)90416-2. [DOI] [PubMed] [Google Scholar]
- Michaeli D., Epstein E. H., Jr Isolation and identification of the antigenic determinants of human collagen. Isr J Med Sci. 1971 Mar;7(3):462–463. [PubMed] [Google Scholar]
- Michaeli D., Martin G. R., Kettman J., Benjamini E., Leung D. Y., Blatt B. A. Localization of antigenic determinants in the polypeptide chains of collagen. Science. 1969 Dec 19;166(3912):1522–1524. doi: 10.1126/science.166.3912.1522. [DOI] [PubMed] [Google Scholar]
- Stiehm E. R., Fudenberg H. H. Serum levels of immune globulins in health and disease: a survey. Pediatrics. 1966 May;37(5):715–727. [PubMed] [Google Scholar]
- Stobo J. D., Tomasi T. B. A Low Molecular Weight Immunoglobulin Antigenically Related to 19 S IgM. J Clin Invest. 1967 Aug;46(8):1329–1337. doi: 10.1172/JCI105625. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vyas G. N., Fudenberg H. H., Pretty H. M., Gold E. R. A new rapid method for genetic typing of human immunoglobulins. J Immunol. 1968 Feb;100(2):274–279. [PubMed] [Google Scholar]
- Wells J. V., Bleumers J. F., Fudenberg H. H. Human anti-IgM iso-antibodies in subjects with selective IgA deficiency. Clin Exp Immunol. 1972 Nov;12(3):305–313. [PMC free article] [PubMed] [Google Scholar]
