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. 1973 Apr;13(4):497–513.

The immune response to [unk]X 174 in man. I. Primary and secondary antibody production in normal adults

D B Peacock, J V Jones, Margaret Gough
PMCID: PMC1553730  PMID: 4197826

Abstract

The bacteriophage [unk]X 174 has been administered intravenously in doses within the range 108–1010 PFU to twenty-six normal human adult volunteers. Antibody was measured as a 50% bacteriophage neutralization titre (SD50). Pre-immunization antibody was found in only one subject. All subjects showed a primary (IgM) response. Peak titres of antibody of 18–8000 occurred between days 6 and 9 in a group of early responders, and between days 14 and 24 in a late group. The secondary response was tested in twenty subjects and peak titres of 1400–50,000 were found in a single group, between days 6 and 13. Thirteen out of fourteen subjects receiving a secondary dose after 6 weeks showed a peak antibody titre between 11,000 and 50,000.

The uniformity of the secondary response indicates that it will be a valuable clinical test of antibody-producing capacity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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