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. 1973 Apr;13(4):561–571.

Autoimmune haemolytic anaemia. VI. 51Chromium survival studies in patients with different kinds of warm autoantibodies

A E G Kr Von Dem Borne, C P Engelfriet, E Reynierse, Do Beckers, J J Van Loghem
PMCID: PMC1553733  PMID: 4717096

Abstract

The results of 51Cr red cell survival and organ sequestration studies in seventysix patients with autoimmune haemolytic anaemia are described.

In patients with incomplete IgG and IgA warm autoantibodies increased red cell destruction to a varying degree and mainly spleen sequestration were found. In patients with IgM incomplete warm autoantibodies sequestration of red cells mainly in the liver was seen. Liver sequestration was also present in patients with cold agglutinins/haemolysis, sometimes accompanied by a significant spleen sequestration. In a number of patients with haemolytic autoantibodies, i.e. warm haemolysins and cold agglutinins/haemolysins, a biphasic 51Cr elimination curve was obtained. The cause of this type of survival curve is discussed.

In patients in whom a positive direct anticomplement test was the only serological abnormality a normal 51Cr red cell life-span was found.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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