Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1973 Jan;13(1):107–124.

The lymphoid organs during pregnancy in the mouse. A comparison between a syngeneic and an allogeneic mating

E S Maroni, Maria A B de Sousa
PMCID: PMC1553755  PMID: 4764346

Abstract

In the present experiments the changes that occur in the central and peripheral lymphoid organs during a first pregnancy in the mouse have been followed up in BALB/c females (H-2d) mated either to males of the same inbred strain or to C3H/Bi males, a strain differing at the major histocompatibility locus (H-2k). Three parameters were examined: weight, morphology and DNA synthesis. The results to be presented strengthen existing evidence that sensitization of the female to foetal transplantation antigens of paternal origin may occur during a first pregnancy and suggest that this process develops at least in part via the lymph nodes draining the uterus.

Full text

PDF
107

Images in this article

114Fig. 3
on p.114
114Fig. 4
on p.114
115Fig. 5
on p.115
115Fig. 6
on p.115
116Fig. 7
on p.116
117Fig. 8
on p.117
119Fig. 9
on p.119

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BURWELL R. G. Studies of the primary and the secondary immune responses of lymph nodes draining homografts of fresh cancellous bone (with particular reference to mechanisms of lymph node reactivity). Ann N Y Acad Sci. 1962 Oct 24;99:821–860. doi: 10.1111/j.1749-6632.1962.tb45365.x. [DOI] [PubMed] [Google Scholar]
  2. Barker C. F., Billingham R. E. The role of regional lymphatics in the skin homograft response. Transplantation. 1967 Jul;5(4 Suppl):962–966. doi: 10.1097/00007890-196707001-00026. [DOI] [PubMed] [Google Scholar]
  3. Boss J. H. Antigenic relationships between placenta and kidney in humans. Am J Obstet Gynecol. 1965 Oct 15;93(4):574–582. doi: 10.1016/0002-9378(65)90519-3. [DOI] [PubMed] [Google Scholar]
  4. Burke C. W., Roulet F. Increased exposure of tissues to cortisol in late pregnancy. Br Med J. 1970 Mar 14;1(5697):657–659. doi: 10.1136/bmj.1.5697.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Currie G. A., Van Doorninck W., Bagshawe K. D. Effect of neuraminidase on the immunogenicity of early mouse trophoblast. Nature. 1968 Jul 13;219(5150):191–192. doi: 10.1038/219191a0. [DOI] [PubMed] [Google Scholar]
  6. Curzen P. The antigenicity of human placenta. J Obstet Gynaecol Br Commonw. 1968 Nov;75(11):1128–1133. doi: 10.1111/j.1471-0528.1968.tb02896.x. [DOI] [PubMed] [Google Scholar]
  7. De Sousa M., Fachet J. The cellular basis of the mechanism of action of cortisone acetate on contact sensitivity to oxazolone in the mouse. Clin Exp Immunol. 1972 Apr;10(4):673–684. [PMC free article] [PubMed] [Google Scholar]
  8. Esteban J. N. The differential effect of hydrocortisone on the short-lived small lymphocyte. Anat Rec. 1968 Nov;162(3):349–356. doi: 10.1002/ar.1091620309. [DOI] [PubMed] [Google Scholar]
  9. Goodman H. S., Masaitis L. Analysis of the isoimmune response to leucocytes: I. Maternal cytotoxic response to fetal lymphocytes. Proc Soc Exp Biol Med. 1967 Nov;126(2):599–604. doi: 10.3181/00379727-126-32517. [DOI] [PubMed] [Google Scholar]
  10. HERZENBERG L. A., GONZALES B. Appearance of H-2 agglutinins in outcrossed female mice. Proc Natl Acad Sci U S A. 1962 Apr 15;48:570–573. doi: 10.1073/pnas.48.4.570. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hellström K. E., Hellström I., Brawn J. Abrogation of cellular immunity to antigenically foreign mouse embryonic cells by a serum factor. Nature. 1969 Nov 29;224(5222):914–915. doi: 10.1038/224914a0. [DOI] [PubMed] [Google Scholar]
  12. Hoggan G, Hoggan F E. On the Comparative Anatomy of the Lymphatics of the Uterus. J Anat Physiol. 1881 Oct;16(Pt 1):50–89. [PMC free article] [PubMed] [Google Scholar]
  13. Hulka J. F., Mohr K. Trophoblast antigenicity demonstrated by altered challenge graft survival. Science. 1968 Aug 16;161(3842):696–698. doi: 10.1126/science.161.3842.696. [DOI] [PubMed] [Google Scholar]
  14. ISHIDATE M., METCALF D. THE PATTERN OF LYMPHOPOIESIS IN THE MOUSE THYMUS AFTER CORTISONE ADMINISTRATION OR ADRENALECTOMY. Aust J Exp Biol Med Sci. 1963 Dec;41:637–649. doi: 10.1038/icb.1963.53. [DOI] [PubMed] [Google Scholar]
  15. ITO T., HOSHINO T. Studies of the influences of pregnancy and lactation on the thymus in the mouse. Z Zellforsch Mikrosk Anat. 1962;57:667–678. doi: 10.1007/BF00410229. [DOI] [PubMed] [Google Scholar]
  16. KALISS N., DAGG M. K. IMMUNE RESPONSE ENGENDERED IN MICE BY MULTIPARITY. Transplantation. 1964 May;2:416–425. doi: 10.1097/00007890-196405000-00011. [DOI] [PubMed] [Google Scholar]
  17. KIRBY D. R., BILLINGTON W. D., BRADBURY S., GOLDSTEIN D. J. ANTIGEN BARRIER OF THE MOUSE PLACENTA. Nature. 1964 Nov 7;204:548–549. doi: 10.1038/204548a0. [DOI] [PubMed] [Google Scholar]
  18. Kirby D. R., Billington W. D., James D. A. Transplantation of eggs to the kidney and uterus of immunised mice. Transplantation. 1966 Nov;4(6):713–718. doi: 10.1097/00007890-196611000-00006. [DOI] [PubMed] [Google Scholar]
  19. MISHELL R. I., HERZENBERG L. A., HERZENBERG L. A. LEUKOCYTE AGGLUTINATION IN MICE; DETECTION OF H-2 AND NON-H-2 ISOANTIGENS. J Immunol. 1963 Apr;90:628–633. [PubMed] [Google Scholar]
  20. Miotti R. Die Lymphknoten und Lymphgefässe der Weissen Ratte (Rattus Norvegicus Berkenhout, Epimys Norvegicus) Acta Anat (Basel) 1965;62(4):489–527. [PubMed] [Google Scholar]
  21. Overweg J., Engelfriet C. P. Cytotoxic leucocyte iso-antibodies formed during the first pregnancy. Vox Sang. 1969 Feb;16(2):97–104. doi: 10.1111/j.1423-0410.1969.tb04722.x. [DOI] [PubMed] [Google Scholar]
  22. PAYNE R. The development and persistence of leukoagglutinins in parous women. Blood. 1962 Apr;19:411–424. [PubMed] [Google Scholar]
  23. PEPPER F. J. The effect of age, pregnancy and lactation on the thymus gland and lymph nodes of the mouse. J Endocrinol. 1961 Jul;22:335–348. doi: 10.1677/joe.0.0220335. [DOI] [PubMed] [Google Scholar]
  24. PORTER K. A., JOSEPH N. H., RENDALL J. M., STOLINSKI C., HOEHN R. J., CALNE R. Y. THE ROLE OF LYMPHOCYTES IN THE REJECTION OF CANINE RENAL HOMOTRANSPLANTS. Lab Invest. 1964 Sep;13:1080–1098. [PubMed] [Google Scholar]
  25. SCOTHORNE R. J., MCGREGOR I. A. Cellular changes in lymph nodes and spleen following skin homografting in the rabbit. J Anat. 1955 Jul;89(3):283–292. [PMC free article] [PubMed] [Google Scholar]
  26. Sörén L. Immunological reactivity of lymphocytes in multiparous females after strain specific matings. Nature. 1967 Feb 11;213(5076):621–622. doi: 10.1038/213621a0. [DOI] [PubMed] [Google Scholar]
  27. VAN ROOD J. J., EERNISSE J. G., VAN LEEUWEN A. Leucocyte antibodies in sera from pregnant women. Nature. 1958 Jun 21;181(4625):1735–1736. doi: 10.1038/1811735a0. [DOI] [PubMed] [Google Scholar]
  28. Van der Werf A. J. Are lymphocytotoxic iso-antibodies induced by the early human trophoblast? Lancet. 1971 Mar 20;1(7699):595–595. doi: 10.1016/s0140-6736(71)91191-3. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES