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. 1973 Jun;14(2):237–245.

Interrelations of humoral and cellular immune responses in experimental canine gastritis

K J E Krohn, N D C Finlayson
PMCID: PMC1553789  PMID: 4717915

Abstract

Experimental canine gastritis is an animal model with features similar to the gastritis of human pernicious anaemia. In this study eight mongrel dogs immunized with autologous or homologous gastric juice in Freund' scomplete adjuvant developed gastritis whereas four mongrel dogs immunized with the adjuvant alone did not. Cellular immunity to gastric juice antigens demonstrated by skin testing and peripheral leucocyte migration inhibition coincided with the appearance of gastritis, whereas parietal cell antibodies appeared some 2 weeks later. The work demonstrates the combined humoral and cellular immune response of the dogs to gastric juice, and suggests that the cellular response may be of primary importance in the development of gastritis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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