Skip to main content
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1973 May;14(1):19–23.

Cytotoxic lymphocytes in Hashimoto thyroiditis: an in vitro assay system using 51Cr-labelled chicken red blood cells coated with thyroglobulin

Elizabeth A Calder, W J Penhale, E W Barnes, W J Irvine
PMCID: PMC1553854  PMID: 4740396

Abstract

An in vitro method is described to detect lymphocytes in patients with Hashimoto thyroiditis that are cytotoxic to thyroglobulin-coated chicken red blood cells. Using this technique, the cytotoxic index of lymphocytes from patients with Hashimoto thyroiditis was 25·46±3·81 (SEM), which is significantly different from that obtained with lymphocytes from control subjects, 6·28±0·80.

Full text

PDF
19

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brostoff J. Migration inhibition studies in human disease. Proc R Soc Med. 1970 Sep;63(9):905–906. doi: 10.1177/003591577006300919. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Calder E. A., McLeman D., Barnes E. W., Irvine W. J. The effect of thyroid antigens on the in vitro migration of leucocytes from patients with Hashimoto thyroiditis. Clin Exp Immunol. 1972 Dec;12(4):429–438. [PMC free article] [PubMed] [Google Scholar]
  3. Cerottini J. C., Nordin A. A., Brunner K. T. Cellular and humoral response to transplantation antigens. I. Development of alloantibody-forming cells and cytotoxic lymphocytes in the graft-versus-host reaction. J Exp Med. 1971 Aug 1;134(2):553–564. doi: 10.1084/jem.134.2.553. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ehrenfeld E. N., Klein E., Benezra D. Human thyroglobulin and thyroid extract as specific stimulators of sensitized lymphocytes. J Clin Endocrinol Metab. 1971 Jan;32(1):115–116. doi: 10.1210/jcem-32-1-115. [DOI] [PubMed] [Google Scholar]
  5. Perper R. J., Zee T. W., Mickelson M. M. Purification of lymphocytes and platelets by gradient centrifugation. J Lab Clin Med. 1968 Nov;72(5):842–848. [PubMed] [Google Scholar]
  6. Podleski W. K. Cytotoxic lymphocytes in Hashimoto's thyroiditis. Clin Exp Immunol. 1972 Aug;11(4):543–548. [PMC free article] [PubMed] [Google Scholar]
  7. Ringertz B., Wasserman J., Packalén T., Perlmann P. Cellular and humoral immune responses in experimental autoimmune thyroiditis. Int Arch Allergy Appl Immunol. 1971;40(6):917–927. doi: 10.1159/000230473. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES